华法林联合毛花苷C治疗老年扩张型心肌病的临床观察  

Clinical observation of warfarin combined with lanatoside C in treatment of elderly patients with dilated cardiomyopathy

作　　者：宋玉新 李莉 赵碧琼 

机构地区：[1]唐山市工人医院心内二科,河北唐山063000

出　　处：《中国生化药物杂志》2015年第5期95-97,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的通过观察华法林、毛花苷C联合治疗老年扩张型心肌病的疗效及其对心功能指标的影响,旨在寻找治疗老年扩张型心肌病的较佳方案。方法选择唐山市工人医院2014年3月~2014年9月收治的扩张型心肌病患者192例,随机分为对照组和治疗组,每组96例。对照组患者给予华法林,治疗组给予华法林和毛花苷C联合治疗。治疗后,评价2组的临床疗效,同时观察并记录患者的左心室射血分数（left ventricular ejection fraction,LVEF）、充盈早期速率/晚期速率（early filling rate/advanced rate,E/A）,舒张早期血流峰值速度（early peak flow velocity,EPFV）、舒张晚期血流峰值速度（atrium peak flow velocity,APFV）,与心脏体积相关的心功能指标：左心室收缩末期容积（left ventricular end systolic volume,LVESV）、左心室舒张末期容积（left ventricular end diastolic volume,LVEDV）、左心室质量（left ventricular mass,LV）,并测量记录心胸比（cardiothoracic ratio,CTR）。行6min步行试验。结果治疗组总有效率（85.42%）显著高于对照组（68.75%）（P〈0.01）。2组患者治疗后LVEF、E/A、EPFV、APFV较治疗前均有显著改善（P〈0.01）,治疗组治疗后上述指标均显著优于对照组（P〈0.01）。2组患者治疗后LVESV、LVEDV、LV和CTR均较治疗前有明显改善（P〈0.01）,治疗组治疗后上述指标改善显著优于对照组（P〈0.05）。2组治疗后6min步行试验均有改善（均P〈0.05）,治疗组改善显著优于对照组（P〈0.05）。2组均未出现明显不良反应。结论华法林与毛花苷C联合治疗老年扩张型心肌病安全有效。Objective To study effect of warfarin combined with lanatoside C on heart function indexes, its curative efficacy in elderly patients with dilated cardiomyopathy, and search for a better therapy for elderly patients with dilated cardiomyopathy.Methods 192 cases of patients with dilated cardiomyopathy were randomly divided into control group and treatment group, 96 cases in each group.Patients in control group were treated with warfarin, and treatment group were given warfarin combined with lanatoside C.After treatment, clinical curative effect evaluation, left ventricular ejection fraction （LVEF）, early filling rate/advanced rate （E/A）, early peak flow velocity （EPFV）, atrium peak flow velocity （APFV）, and cardiac indexes related to cardiac volume： left ventricular end systolic volume （LVESV）, left ventricular end diastolic volume （LVEDV）, left ventricular mass （LV）, cardiothoracic ratio （CTR）, and 6min walk test were observed and recorded in two groups.Results The total effective rate in treatment group （85.42%） was significantly higher than that of control group （68.75%, P〈0.01）.The LVEF, E/A, EPFV, APFV in two groups of patients were improved compared with those before treatment （P〈0.01）, and the improvement of the above indexes in treatment group were significantly better than those in control group （P〈0.01）.The LVESV, LVEDV, LV, and CTR were improved in two groups after treatment than before treatment （P〈0.01）, and the improvement of above indexes in treatment group were significantly better than control group after treatment（P〈0.05）.6min walking test results were improved in two groups after treatment than before treatment （ P〈0.05 ） , and the treatment group was significantly better than control group （P〈0.05）.There were no significant differences between two groups in adverse reactions.Conclusion Warfarin combined with lanatoside C in the treatment of elderly patients with dilated cardiomyopathy is a safe and effective treatme

关 键 词：华法林 毛花苷C 扩张型心肌病 老年 

分 类 号：R972[医药卫生—药品]