瑞舒伐他汀对冠心病患者心功能、血脂水平、血液流变学水平及内皮功能的影响  

Impact of rosuvastatin on cardiac function,lipid levels,blood rheology level and endothelial function in patients with coronary artery disease

作　　者：郭华[1] 陈炅[1] 索冬卫[1] 

机构地区：[1]郑州大学第五附属医院急诊科,河南郑州450052

出　　处：《中国生化药物杂志》2015年第5期98-100,104,共4页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的探讨瑞舒伐他汀对冠心病患者心功能、血脂水平、血液流变学水平及内皮功能的影响。方法 149例患者随机分为2组,分别为治疗组(n=76)和对照组(n=73)。对照组采用常规对症治疗,治疗组在此基础上结合瑞舒伐他汀治疗。对比分析2组治疗前后心功能、血脂水平、血液流变学水平及血管内皮功能水平变化。结果治疗后,2组LVEF高于治疗前(P<0.05),而LVESV、LVEDV低于治疗前(P<0.05);治疗后,治疗组LVEF高于对照组(P<0.05),LVESV、LVEDV低于对照组(P<0.05);治疗后,2组LDL-C、TC、TG低于各组间治疗前(P<0.05),而HDL-C高于各组治疗前(P<0.05);治疗后,治疗组LDL-C、TC、TG低于对照组(P<0.05),HDL-C高于对照组(P<0.05);治疗后,2组纤维蛋白原、血浆黏度、全血低切黏度、全血高切黏度低于治疗前(P<0.05);治疗后,治疗组纤维蛋白原、血浆黏度、全血低切黏度、全血高切黏度低于对照组(P<0.05);治疗后,2组NO、FMD高于各组间治疗前(P<0.05),而ET低于各组间治疗前(P<0.05);治疗后,治疗组NO、FMD高于对照组(P<0.05),而ET低于对照组(P<0.05)。结论瑞舒伐他汀可明显改善患者心功能、改善血脂水平、降低血液流变学水平、改善血管内皮功能。Objective To investigate impact of rosuvastatin on cardiac function, lipid levels, blood rheology level and endothelial function in patients with coronary heart disease.Methods 149 cases were randomly divided into two groups, the treatment group （n=76） and control group（n=73）.Control group with conventional symptomatic treatment, treatment group on the basis of control group combined rosuvastatin treatment.Cardiac function, blood lipid levels, blood rheology changes and endothelial function levels before and after treatment were comparative analysis.Results LVEF significantly increased after treatment than before treatment between two groups （P〈0.05）, while LVESV, LVEDV after treatment than before treatment were significantly lower （ P〈0.05 ） , LVEF in treatment group was significantly higher than control group （ P〈0.05 ） , LVESV, LVEDV was significantly lower than that of control group （P〈0.05）.The two groups of LDL-C, TC, TG after treatment was significantly lower than before treatment （P〈0.05）, but HDL-C was higher than before treatment（P〈0.05）.LDL-C, TC, TG in treatment group after treatment was significantly lower than control group （P〈0.05）, whereas HDL-C after treatment was significantly higher than control group （P〈0.05）.Fibrinogen, plasma viscosity, whole blood low shear viscosity, whole blood viscosity was lower than that before treatment （P〈0.05）, which in treatment group was significantly lower than control group （P〈0.05）.NO, FMD was significantly higher than before treatment （P〈0.05）, and ET was significantly lower than before treatment （P〈0.05）.NO, FMD in treatment group was significantly higher than control group （P〈0.05）, and ET was significantly lower than control group （P〈0.05）.Conclusion Rosuvastatin can significantly improve cardiac function, improve blood lipid levels, lower levels of blood rheology, improve endothelial function.

关 键 词：瑞舒伐他汀 冠心病 心功能 血脂 血液流变学 内皮功能 

分 类 号：R541.4[医药卫生—心血管疾病]