中药黄芪水煎剂对慢性心衰患者内分泌激素及心功能影响研究  

Effect of endocrine hormone and cardiac function on patients with chronic heart failure by Huangqi Decoction

作　　者：王晶 高海旺 李月萍 

机构地区：[1]山西潞安集团总医院内科,山西长治046204 [2]山西潞安集团总医院心内科,山西长治046204 [3]山西潞安集团总医院中医科,山西长治046204

出　　处：《中国生化药物杂志》2015年第5期101-104,共4页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的探讨黄芪煎剂对心力衰竭患者抗心衰治疗前后神经内分泌激素及心脏射血力变化。方法选取山西潞安集团总医院已确诊为慢性心衰患者100例,随机分为和对照组和中药组(n=50),对照组采用常规治疗,中药组在对照组的基础上给予黄芪煎剂,治疗2周。检测并比较2组患者治疗前后血浆神经内分泌激素指标,并利用心脏彩超评估射血力。结果与对照组相比较,中药组患者抗心衰治疗效果更好,表现为:血浆降钙素基因相关肽(CGRP)、心房钠尿肽(ANP)、C型利钠肽(CNP)、神经肽Y(NPY)水平明显较低(P<0.05);心功能容量指标明显改善(P<0.05);左房内径、左房最大、最小容积显著减小(P<0.05);左心房、左心室射血力明显升高(P<0.05)。结论黄芪煎剂能够抑制心力衰竭患者CGRP、ANP、CNP、NPY等神经内分泌激素的分泌,减轻心脏负荷,增加心脏射血力。Objective To analyse change of neuroendocrine hormone and cardiac ultra ejection force in patients with heart failure before and after treatment with Huangqi Decoction.Methods 100 patients diagnosed with chronic heart failure were collected.According to the different treatment regimens divided into two groups （ control group： conventional western medicine; traditional Chinese medicine group： conventional western medicine treatment ＋Astragalus Decoction orally for 2 weeks） , before and after treatment,nerve endocrine hormone using echocardiography evaluation index and ejection force were detected in two groups, and compare the results of data.Results Compared with control group, Chinese medicine group with better anti heart failure treatment, performance： the plasma calcitonin gene related peptide （CGRP）, atrial natriuretic peptide （ANP）, C type natriuretic peptide （ CNP ） , neuropeptide Y （ NPY ） levels were significantly lower （ P〈0.05 ） . Capacity index significantly improved cardiac function （P〈0.05）.Left atrial diameter, left atrial maximum, minimum volume decreased significantly （P〈0.05）.Ejection force of left atrium and left ventricular increased significantly （ P〈0.05 ） .The results were statistically significant.Conclusion Huangqi decoction can inhibit the secretion of CGRP, ANP, CNP,NPY and other neuroendocrine hormones in patients with heart failure, reduce cardiac load, increase cardiac ejection force.

关 键 词：心力衰竭 黄芪煎剂 神经内分泌激素 射血力 

分 类 号：R541[医药卫生—心血管疾病]