New Delhi Metallo-β-Lactamase-Mediated Carbapenem Resistance： Origin, Diagnosis, Treatment and Public Health Concern  

作　　者：Wen-Juan Wei Hai-Fei Yang Ying Ye Jia-Bin Li 

机构地区：[1]Department of Infectious Disease, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China [2]Department of Infectious Disease, Chaohu Hospital of Anhui Medical University, Hefei, Anhui 238000, China [3]Department of Molecular Biology, Institute of Bacterium Resistance, Anhui Medical University, Hefei, Anhui 230022, China [4]Anhui Center for Surveillance of Bacterial Resistance. Hefei. Anhui 230022. China

出　　处：《Chinese Medical Journal》2015年第14期1969-1976,共8页中华医学杂志（英文版）

基　　金：Source of Support： This study was supported by grants from National Natural Science Foundation of China （No. 81101288 and 81172737）. Conflict of Interest： None declared.

摘　　要：Objective： To review the origin, diagnosis, treatment and public health concern of New Delhi metallo-β-lactamase （NDM）-producing bacteria. Data Sources： We searched database for studies published in English. The database of PubMed from 2007 to 2015 was used to conduct a search using the keyword term ＂NDM and Acinetobacter or Enterobacteriaceae or Pseudomonas aeruginosa.＂ Study Selection： We collected data including the relevant articles on international transmission, testing methods and treatment strategies of NDM-positive bacteria. Worldwide NDM cases were reviewed based on 22 case reports. Results： The first documented case of infection caused by bacteria producing NDM- 1 occurred in India, in 2008. Since then, 13 blaNDM variants have been reported. The rise of NDM is not only due to its high rate of genetic transfer among unrelated bacterial species, but also to human factors such as travel, sanitation and food production and preparation. With limited treatment options, scientists try to improve available therapies and create new ones. Conclusions： In order to slow down the spread of these NDM-positive bacteria, a series of measures must be implemented. The creation and transmission of blaNDM are potentially global health issues, which are not issues for one country or one medical community, but for global priorities in general and for individual wound care practitioners specifically.Objective： To review the origin, diagnosis, treatment and public health concern of New Delhi metallo-β-lactamase （NDM）-producing bacteria. Data Sources： We searched database for studies published in English. The database of PubMed from 2007 to 2015 was used to conduct a search using the keyword term ＂NDM and Acinetobacter or Enterobacteriaceae or Pseudomonas aeruginosa.＂ Study Selection： We collected data including the relevant articles on international transmission, testing methods and treatment strategies of NDM-positive bacteria. Worldwide NDM cases were reviewed based on 22 case reports. Results： The first documented case of infection caused by bacteria producing NDM- 1 occurred in India, in 2008. Since then, 13 blaNDM variants have been reported. The rise of NDM is not only due to its high rate of genetic transfer among unrelated bacterial species, but also to human factors such as travel, sanitation and food production and preparation. With limited treatment options, scientists try to improve available therapies and create new ones. Conclusions： In order to slow down the spread of these NDM-positive bacteria, a series of measures must be implemented. The creation and transmission of blaNDM are potentially global health issues, which are not issues for one country or one medical community, but for global priorities in general and for individual wound care practitioners specifically.

关 键 词：BACTERIAL Carbapenem Resistance Drug Resistance New Delhi Metallo-β-Lactamase 

分 类 号：TQ465[化学工程—制药化工] Q939.112[生物学—微生物学]