乌司他丁对腹腔镜妇科不孕症手术患者T淋巴细胞免疫功能的影响  

Effect of Ulinastatin on T-cytoimmunity in patients with infetility undergoing laparoscopic surgery

作　　者：邓恋[1] 胡祖荣[1] 易菁[1] 苏丹晨[1] 蔡诚毅[2] 

机构地区：[1]广东省妇幼保健院麻醉科,广州市510165 [2]广州中医药大学第一附属医院麻醉科,510405

出　　处：《实用医学杂志》2015年第13期2081-2083,共3页The Journal of Practical Medicine

基　　金：2010年天普研究基金项目(编号:01201033)

摘　　要：目的：探讨乌司他丁对腹腔镜手术患者T细胞免疫功能的保护作用。方法：选取40例拟行腹腔镜手术的不孕症患者，随机分成乌司他丁组（u组）和对照组（C组），每组20例。U组静滴鸟司他丁20万U＋生理盐水100mL，15min滴完，然后进行麻醉和手术。C组静滴生理盐水100mL，余同U组。采集术前（R）、术毕（T1）、术后1d（T2）、术后3d（T3）的静脉血，测定T细胞亚群（CD3＋、CD3＋CD4＋、CD3＋CD8＋）的水平，计算CD3＋CD4＋／CD3＋CD8＋比值。结果：与Tn比较，C组CD3＋在T1-3无明显变化，U组在T2～3明显升高，与C组比较差异有显著性。C组CD3＋CD4＋仅T3升高，U组在T2=3明显升高。C组CD3＋CD8＋在T2-3明显升高，u组在T1-3无明显变化，T]时两组间比较差异有显著性；C组CD3＋CD4＋／CD3＋CD8＋在T1～3无明显变化，U组T1时明显升高。结论：在腹腔镜手术中应用乌司他丁能有效恢复患者因手术所致抑制的细胞免疫功能，有利于促进患者术后的恢复。Objective To research the effect of ulinastatin on T-cytoimmunity in patients with infertility undergoing laparoscopic surgery. Methods Forty patients scheduled for receiving laparoscopic surgery were equally randomized into two groups, ulinastatin group （Group U） and control group （Group C）. Ulinastatin was given to patients in the Group U at a dose of 20 × 104 U before anesthetic. No ulinastatin was given to patients in the Group C. Patients＇venous blood samples for T-lymphocyte subset （CD3＋, CD3＋CD4＋, CD3＋CD8＋） and CD3＋ CD4＋/ CD3＋CD8＋ ratio calculation were collected before the surgery （To） and at 0 h （T1）, 1st day （T2）,3rd day （T3） after the surgery. Results CD3＋ had less difference at T1-3 compared with To in the Group C but raised obviously at T2-3 in the Group U. CD3＋CD4＋ were only raised at T3 compared with To but raised obviously at T2-3 in the Group U. CD3＋CD8＋ were raised obviously at T2-3 compared with To in the Group C but had less difference in the Group U. CD3＋CD4＋/CD3＋CD8＋ had less difference at T1-3 compared with To in the Group C but raised obviously at T3 in the Group U. Conclusion The application of ulinastatin in laparoscopic surgery could significantly produce protective effect on T-cytoimmunity.

关 键 词：乌司他丁 腹腔镜 免疫 T淋巴细胞 

分 类 号：R713.7[医药卫生—妇产科学]