右美托咪定对体外循环围术期炎症因子的影响及其对肝肾功能的保护作用  

Effect of dexmedetomidine on patients′ inflammation during the CPB and the effect on patients′ renal and hepatic function

作　　者：秦俊[1] 秦再生[1] 朱晨[1] 刘琳琳[1] 陶涛[1] 

机构地区：[1]南方医科大学南方医院,广州市510515

出　　处：《实用医学杂志》2015年第13期2087-2089,共3页The Journal of Practical Medicine

基　　金：广东省医学科学技术研究基金资助项目(编号:A2012366);南方医科大学南方医院院长基金资助项目(编号:211B007)

摘　　要：目的：观察右美托咪定对体外循环（CPB）围术期炎症因子的影响及其对肝肾功能的保护作用。方法：选取择期行CPB瓣膜置换术患者60例，随机分生理盐水组（NS组）和右美托咪定组（DEX组）。分别于T，（手术前）、T2（升主动脉阻断前）、T3（转流结束时）、T4（术后24h）、T5（术后48h）、T6（术后72h）6个时间点计数WBC和中性粒细胞百分比及测定血清HMGB-1、TNF-α、IL-6、BUN、Cr、ALT的含量。结果：两组除ALT外．其他指标相比除T1时点外。R2～R5个时点DEX组均显著低于NS组（P〈0．05）。两组血清ALT在R、L2个时点比较差异有统计学意义，DEX组明显低于NS组（P〈0．05）。结论：DEX可显著降低CPB期间外周血清炎症因子的水平，改善术后肾功能，而对术后肝功能的保护作用可能不明显。Objective To observe the effect of dexmedetomidine on patients＇ inflammation during CPB and protective effect on kidney and liver. Methods 60 eases undergoing cardiac valve replacement under CPB were randomly divided into NS group and Dex group. Blood samples were taken before induction, before ascending aorta blocked, end of CPB, 24, 48 and 72 hours after operation. The serum level of HMGB-1, TNF- or, IL-6, BUN, Cr and ALT are tested. Blood WBC and N% are also counted. Results WBC, N% and HMGB-1, TNF-α, IL-6, BUN, Cr in Dcx group significantly decreased at time point T2 - T6 （P 〈 0.05） compared with NS group. But ALT in Dex group only decreased at time point T2 and T5 compared with NS group （P 〈 0.05）. Conclusion Dexmedetomidine can significantly decrease inflammatory factor during CPB and improve renal function after surgery.

关 键 词：右美托咪定 HMGB-1 TNF-Α IL-6 体外循环 

分 类 号：R614[医药卫生—麻醉学]