类叶升麻苷的药理作用及药物代谢动力学研究进展  

Advances in studies of pharmacodynamics and pharmacokinetics of acteoside

作　　者：文彦丽[1] 霍仕霞 张伟[1] 邢晗[1] 祁麟 赵娣[1] 李宁[1] 闫明 陈西敬[1] 

机构地区：[1]中国药科大学药物代谢与动力学研究中心,江苏南京211198 [2]新疆维吾尔自治区维吾尔医药研究所,新疆乌鲁木齐830049 [3]中国医学科学院血液病医院,天津300020

出　　处：《中国民族民间医药》2015年第14期26-27,29,共3页Chinese Journal of Ethnomedicine and Ethnopharmacy

基　　金：新疆维吾尔自治区科研机构创新发展专项基金(NO.2014003)

摘　　要：目的:总结类叶升麻苷药理作用及药动学研究进展,为开发研究提供参考依据。方法:查阅相关的文献报道进行综述。结果:类叶升麻苷药理作用广泛,尤其是抗氧化、抗衰老、增强记忆和神经保护作用等更为突出。其吸收迅速,生物利用度较低,体内分布广泛且存在系统前代谢情况。结论:类叶升麻苷药理活性强、毒副作用小,具有很好的开发前景。Objective Summary pharmacodynarnics and pharmacokinetics of aeteoside to provide reference for further development. Method Search and overview the reported relevant literature. Results Acteoside has extensive and potent biological activities, especially the antioxidant, anti - aging, as well as cytoprotective effects and memory - enhancing. And acteoside is absorbed quickly with low bioavailability, extensive distribution and presystemie metabolism. Conclution Acteoside is a promising drug for further research with potent biological activities and low toxicity.

关 键 词：类叶升麻苷 药理作用 药动学 

分 类 号：R285[医药卫生—中药学]