1000例慢性HBV感染者临床病毒学特征  

作　　者：刘娜[1] 李春霞[1] 徐光华[1] 吴殿磊[1] 武琼[1] 任婷婷[1] 

机构地区：[1]延安大学附属医院感染病科,陕西延安716000

出　　处：《医学与社会》2015年第B05期19-20,共2页Medicine and Society

基　　金：延安市科技计划项目（2009ks-16）

摘　　要：目的：研讨慢性HBV感染者在20—40岁年龄阶段临床病毒学特征，为临床个体化治疗提供思路。方法：用实时荧光定量聚合酶链反应（FQ—PCR）及时间分辩荧光免疫分析（TRFIA）技术检测1000例（20—40岁）慢性HBV感染者血清中HBVDNA、HBsAg、HBeAg含量，用速率法检测ALT水平。结果：男女两组在传播方式上没有差别（x2=2753，P=0．097）；不同临床类型HBVDNA、HBVM定量和ALT之间的比较：HBsAg水平在ASC组、CHB组、LC组逐渐降低（P〈0．05）；CHB组血清HBeAg定量、HBVDNA水平高于ASC组、Lc组（P〈0．05）；ALlT水平在各组间比较具有显著性差异（P〈0．05）。结论：男女对HBV都普遍易感；20—40岁慢性HBV感染者临床病毒学特征符合其自然病程。Objective To discuss the chronic HBV infection in clinical virology features 20 -40 years old age stage for providing ideas for clinical individualized treatment. Methods The serum HBV DNA content,HBV M quantity of 1000 cases in all between 20 -40 years old infected with HBV were examined by real time fluorescence quantitative poly- merase chain reaction （ FQ - PCR） and time - resolved ALT were determined by rate There is a difference on two groups of men and women in the mode of transmission （ X2 = 2. 753, P = 0. 097 ）. There is a difference on two groups of men and women in the mode of transmission. Different clinical types of HBV DNA and HBV M comparison between quantitative and ALT： HBsAg levels in ASC, CHB group, LC group gradually reduced（P 〈0. 05） . CHB group serum HBeAg, HBV DNA levels higher than the ASC group, quantitative IX： group （P 〈0. 05） , ALT levels compared with significant difference between groups（P 〈0. 05）. Conclusion Men and women are generally susceptible to HBV. 20 -40 years old with chronic HBV infection clinical virology features Conform to with its natural course.

关 键 词：20—40岁 慢性HBV感染 HBV DNA HBSAG定量 

分 类 号：R373.21[医药卫生—病原生物学]