PAPP-A水平与冠状动脉临界病变斑块显像特征关系的探讨  

Relationship between PAPP-A Levels and Coronary Artery Critical Lesion Plaque Imaging Characteristics

作　　者：费玲[1] 张军[1] 牛和平[1] 付金国[1] 马晓丽[1] 

机构地区：[1]河北省医科大学附属沧州市中心医院心内科,沧州061001

出　　处：《中国医药导刊》2015年第7期657-658,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:探讨血清妊娠相关血浆蛋白A(PAPP-A)水平与冠状动脉临界病变斑块稳定性的关系。方法:经过量化冠状动脉造影证实冠状动脉狭窄处于临界病变的冠心病患者110例,分为介入组(A组)58例和非介入组(B组)52例,用血管内超声(IVUS)定量检测两组冠状动脉临界病变斑块显像指标;入选冠状动脉造影正常者为对照组(C组)50例。用ELSLA法测定三组血清PAPP-A水平,比较血清PAPP-A水平与IVUS检测指标的相关性。结果:A组血清PAPP-A水平明显高于B组及C组(P均<0.01),有统计学差异。IVUS显示A组病变血管的斑块面积和血管重构指数、斑块负荷和偏心指数均显著大于B组,P均<0.05;最小管腔面积明显小于B组(P<0.05)。A组斑块多为不稳定性斑块,血清PAPP-A水平与斑块偏心指数、血管重构指数呈显著正相关(P<0.05),与最小管腔面积成负相关(P<0.05)。结论:血清PAPP-A与IVUS测定的斑块易损指标相关,可作为评价冠状动脉粥样硬化斑块稳定性的指标。Objective： To investigate the relationship between serum pregnancy associated plasma protein A（PAPP-A） levels and the stability of the coronary lesions in the critical coronary artery lesions. Methods： By quantitative coronary angiography of coronary artery stenosis in 110 cases of borderline lesions in patients with coronary heart disease, divided into intervention group（group A） 58 cases and non intervention group（group B） in 52 cases, with Intravascular ultrasound（IVUS） quantitative detection of two groups of coronary borderline lesions plaque imaging parameters. The selected subjects with normal coronary angiography as control group（C group） 50 cases. The serum PAPP-A levels of the three groups were determined by ELSLA, and the correlation between serum PAPP-A and IVUS was detected. Results： The levels of serum PAPP-A in A group were significantly higher than that in B group and C group（P〈0.01）, and there were statistically significant differences. IVUS showed a group of vascular lesions of patch area and vascular remodeling index, plaque load and eccentric index were significantly higher than that of group B, P〈0.05; minimum lumen area was significantly less than in group B（P〈0.05）. A plaque group for unstable plaque, serum levels of PAPP-A and plaque eccentricity index and vascular remodeling index showed significant positive correlation（P〈0.05）, and minimal lumen area into a negative correlation（P〈0.05）. Conclusions： The serum PAPP-A and IVUS were correlated with the plaque vulnerability index, and can be used as the index of evaluating the stability of coronary atherosclerotic plaque.

关 键 词：冠状动脉临界病变 PAPP-A 血管内超声 

分 类 号：R54[医药卫生—心血管疾病]