2型糖尿病患者同型半胱氨酸与凝血指标结果分析  

The results analysis of homocysteine and blood coagulation index in patients with type 2 diabetes

作　　者：厉吉霞[1] 王梅春[1] 杨红梅[1] 

机构地区：[1]山东省烟台市烟台山医院检验科,山东烟台264001

出　　处：《医学检验与临床》2015年第3期13-15,共3页Medical Laboratory Science and Clinics

摘　　要：目的：回顾性分析2型糖尿病患者糖化血红蛋白（HbA1c）、同型半胱氨酸（Hcy）、凝血指标的关系。方法：152例2型糖尿病患者以糖化血红蛋白6.5%为临界，分为血糖控制良好组（HbA1c〈6.5%）及血糖控制不良组（HbA1c〉6.5%），同时，选取30例健康体检者为正常对照组，比较各组间同型半胱氨酸（Hcy）及凝血指标（PT, APTT ,TT, FIB-C）的差异，并分析各指标与糖化血红蛋白水平的相关性。结果：与对照组比较，糖尿病控制良好组 Hcy显著增高（P〈0.05），凝血指标变化不具有统计学意义；糖尿病控制不良组较其他两组，Hcy显著增高（P〈0.01）， APTT显著下降（P〈0.05），FIB-C显著上升（P〈0.05）；糖尿病患者同型半胱氨酸（Hcy）水平、APTT缩短与糖化血红蛋白（HbA1c）呈正相关。结论：血浆Hcy水平及凝血功能异常可能是导致糖尿病并发症的危险因素。Objective：To observe relational changes of plasma glycated hemoglobin （HbA1c）,homocysteine（Hcy） and coagulation in patients with type 2 diabetes.Methods：152 cases of patients with type 2 diabetes were divided into good glycemic control group（HbA1c〈6.5% ） and poor glycemic control group （HbA1c〉6.5%）, and 30 cases of normal controls were collected. Plasma glycated hemoglobin （HbA1c）, homocysteine（Hcy） ,coagulation parameters （PT, APTT, TT, FIB-C） were measured and compared among the three groups, in addition, the correlations between Hcy ,PT, APTT, TT, FIB-C and HbA1c were analyzed. Results： Hcy of good glycemic control group was higher than normal group（P〈 0.05）, while the changes of PT, APTT, TT, FIB - C were not obvious. Compared with good glycemic control group and normal control group, poor glycemic control group showed significantly higher Hcy （P〈 0.01） ,shorter APTT（P〈 0.05） and elevated FIB-C（P〈 0.05）. The result displayed the positive correlations between Hcy ,APTT shortening and HbA1c of the patients with type 2 diabetes.Conclusions：Plasma Hcy levels and abnormal coagulation could be the risk factor of diabetes complications.

关 键 词：2型糖尿病 同型半胱氨酸 糖化血红蛋白 凝血 

分 类 号：R714.12[医药卫生—妇产科学]