眼用原位凝胶研究进展  

Recent Advances of in Situ Gel for Ocular Drug Delivery

作　　者：李颖[1] 汤湛[1] 王俏[1] 

机构地区：[1]浙江省医学科学院药物研究所,杭州310013

出　　处：《中国药学杂志》2015年第14期1174-1179,共6页Chinese Pharmaceutical Journal

基　　金：浙江省医学重点学科群项目(XKQ-010-001);浙江省科技计划项目(2012F10005);浙江省医科院青年基金资助项目(2013Y002);浙江省医药卫生科技项目(2014KYB068)

摘　　要：原位凝胶是一类以溶液状态给药,并在生理环境下相变为凝胶状态的聚合物,具有溶液和凝胶的双重优势。普通滴眼液存在滞留时间短,生物利用度低等问题。近年已有较多文献将新型原位凝胶应用于眼部给药,通过延长眼部滞留时间来提高药物在眼部的生物利用度。笔者通过文献检索,从原位凝胶的分类及在眼部给药系统中的应用等方面,论述不同类别原位凝胶的研究现状和关键技术性问题,并分析了眼用原位凝胶的未来发展趋势。In situ gel is liquid upon instillation and undergo phase transition under physiological conditions to form visco-elastic gel with dual advantages of liquid and gel. Ordinary eye drops exist a problem of short residence time with low bioavailability. In recent years, an impressive number of novel in situ gel systems have been reported for ocular drug delivery to increase bioavailability with the extension of corneal residence time. In this article, the classification and application about in situ gel for ocular drug delivery are reviewed, then the study status and the key technical problem of the in situ ophthalmic gel in detail are described. In addition, the future advancement of this field is also discussed.

关 键 词：原位凝胶 眼部给药系统 聚合物 

分 类 号：R944[医药卫生—药剂学]