婴儿巨细胞病毒性肝炎36例临床分析  

Clinical analysis of 36 cases with infantile cytomegalovirus hepatitis

作　　者：封洁 庄丽丽 朱亮华 邱灵芝 周国平 

机构地区：[1]南京医科大学第一附属医院儿科,江苏省210029

出　　处：《江苏医药》2015年第14期1646-1648,共3页Jiangsu Medical Journal

基　　金：国家自然科学基金(30872804;81170661);教育部博士点基金(20113234110010);江苏省研究生培养创新工程(CXZZ11_0714)

摘　　要：目的观察婴儿巨细胞病毒(CMV)性肝炎的临床特点及更昔洛韦的治疗效果。方法回顾性分析36例住院CMV肝炎婴儿的临床特点,评价28例应用更昔洛韦治疗疗效及其不良反应。结果 CMV肝炎婴儿均有肝功能异常,表现为血清谷丙转氨酶(94.4%)、谷草转氨酶(91.7%)及γ-谷氨酰转肽酶(52.8%)不同程度的升高,总胆红素多为轻中度升高(30.6%)。部分患儿出现黄疸(25.0%)、肝脏肿大(25.0%)和脾脏肿大(8.3%)。易合并心肌损害(83.3%)、肺炎或支气管炎(38.9%)。更昔洛韦治疗后患儿症状缓解,肝功能指标均有不同程度的下降,不良反应轻。结论婴儿CMV肝炎大部分预后良好;更昔洛韦治疗婴儿CMV肝炎疗效肯定,安全性好。Objective To observe the clinical features of infantile cytomegalovirus（CMV）hepatitis and the efficacy of ganciclovir in treating infantile CMV hepatitis.Methods The clinical features of 36 hospitalized infants with CMV hepatitis were retrospectively analyzed,of whom 28 cases were treated with ganciclovir.The clinical efficacy and adverse effects were assessed.Results All 36 patients with CMV hepatitis had abnormal liver functions of elevated serum alanine aminotransferase（94.4%）,aspartate aminotransferase（91.7%）,γ-glutamyl peptidase（52.8%）and total bilirubin（30.6%）.Some of the patients were with jaundice（25.0%）,hepatomegaly（25.0%）,splenomegaly（8.3%）,myocardial damage（83.3%）and pneumonia or bronchitis（38.9%）.Ganciclovir in treating infantile CMV hepatitis can effectively attenuate clinical symptoms and improve liver functions with less side effects.Conclusion The prognosis of most infants with CMV hepatitis is good and ganciclovir is effective and safe in treating infantile CMV hepatitis.

关 键 词：婴儿 巨细胞病毒肝炎 更昔洛韦 

分 类 号：R725[医药卫生—儿科]