寻常性银屑病表皮内质网氨肽酶1蛋白的表达  被引量:1

Expression of endoplasmic reticulum aminopeptidase 1 in epidermis of psoriasis vulgaris

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作  者:许丽娜[1] 冯艳燕[2] 普雄明[2] 

机构地区:[1]石河子大学医学院,新疆石河子832003 [2]新疆维吾尔自治区人民医院皮肤科,新疆乌鲁木齐830000

出  处:《临床皮肤科杂志》2015年第8期481-483,共3页Journal of Clinical Dermatology

基  金:新疆维吾尔自治区人民医院院内科研基金(20130111)资助项目

摘  要:目的:探讨寻常性银屑病患者表皮内质网氨肽酶1(endoplasmic reticulum aminopeptidase 1,ERAP1)的表达特征。方法:应用免疫组化方法对49例经临床及组织病理确诊为银屑病、临床分期为典型进展期和稳定期的寻常性银屑病患者的皮损组织进行ERAP1蛋白的表达检测。结果:进展期、稳定期银屑病患者皮损处均有ERAP1蛋白表达,但表达方式存在组织学差异。与进展期相比,稳定期ERAP1蛋白主要在表皮层呈弥漫、均一阳性表达;与稳定期相比,进展期ERAP1蛋白在表皮层内的表达分布呈非弥漫均一性,而以表皮上部较强、下部较弱为特征(χ2=19.53,P<0.001,OR=26.16)。结论:寻常性银屑病表皮内ERAP1蛋白表达存在差异。Objective: To investigate the expression of endoplasmic reticulum aminopeptidase(ERAP) 1 in the epidermis of the skin lesion of psoriasis vulgaris. Methods: Immunohistochemistry staining was used to detect the expression of ERAP1 in the epidermis of the skin lesion of the patients with psoriasis vulgaris of typical progressive and resting stages. Results: The expression levels of ERAP1 were both high in the epidermis of the skin lesion of the patients with psoriasis vulgaris in the two different stages, but the distribution varied histopathologically. Compared with the progressive stage, the ERAP1 ex- pression was diffuse and uniform in the resting stage. Different from the resting stage, the ERAP1 expression in the progres- sive stage was stronger in the upper epidermis and weaker in the lower epidermis(x^2=19.53,P〈0.001, OR=26.16). Conclusion: The expression of ERAP1 is different in the epidermis of the skin lesion of psoriasis vulgaris.

关 键 词:银屑病 临床分期 表皮内质网氨肽酶1 免疫组化 

分 类 号:R758.63[医药卫生—皮肤病学与性病学]

 

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