燃煤型地方性氟中毒病区8～14岁儿童血清BMP-2、BMP-3水平  

Serum BMP-2 and BMP-3 Levels in Children of 8-14 Years Old in Coal-Burning Endemic Fluorosis Areas

作　　者：吴延莉 曹发军[1] 范祥[1] 徐小东[1] 向蓉[1] 曾贝贝[1] 韦艳[1] 谢春[1] 金庭旭[1] 张华[1] 

机构地区：[1]贵州医科大学公共卫生学院环境卫生学教研室,贵州550004

出　　处：《环境与职业医学》2015年第7期615-619,共5页Journal of Environmental and Occupational Medicine

基　　金：科技部国家科技支撑计划课题(编号:2013BAI05B03);国家自然科学基金资助项目(编号:81360412)

摘　　要：[目的]观察燃煤型氟中毒病区儿童血清骨形态发生蛋白-2(BMP-2)和骨形态发生蛋白-3(BMP-3)的表达情况。[方法]对贵州省六盘水市水城县陡箐乡某两所小学(氟病区)366名和花嘎乡某所小学(对照区)120名8~14岁在校儿童进行氟斑牙和尿氟浓度调查;根据知情同意原则,选取氟病区(根据氟斑牙的分级)115例和对照区57例在校儿童,收集血清,检测血清BMP-2、BMP-3的浓度。[结果]氟病区儿童氟斑牙检出率为61.5%,对照区儿童无氟斑牙发生;氟病区儿童尿氟浓度[M(P25,P75)][0.77(0.536,1.136)mg/L]较对照区[0.49(0.370,0.660)mg/L]高,差异均有统计学意义(χ2氟斑牙=265.130,P氟斑牙<0.05;Z尿氟=-7.716,P尿氟<0.05)。氟病区儿童血清BMP-2、BMP-3浓度[M(P25,P75)]为[16.40(13.51,27.08)、155.39(132.57,177.95)ng/L]较对照区儿童血清BMP-2、BMP-3浓度[18.73(14.89,25.84)、163.67(149.18,190.74)ng/L]低,差异均有统计学意义(ZBMP-2=-2.023,PBMP-2<0.05;ZBMP-3=-2.736,PBMP-3<0.01)。氟病区13~14岁组儿童血清BMP-3浓度[139.52(122.53,159.07)ng/L]较对照组[174.05(154.15,195.03)ng/L]低,差异有统计学意义(Z=-2.967,P<0.01)。氟病区儿童血清BMP-2、BMP-3浓度在不同程度氟斑牙之间差异无统计学意义(χ2BMP-2=4.680,PBMP-2=0.322;χ2BMP-3=2.649,PBMP-3=0.618)。氟病区儿童血清BMP-2、BMP-3浓度在不同尿氟浓度水平之间差异无统计学意义(χ2BMP-2=1.292,PBMP-2=0.731;χ2BMP-3=1.440,PBMP-3=0.696)。[结论]贵州省六盘水市氟病区儿童血清BMP-2、BMP-3浓度较低,氟可能影响血清BMP-2、BMP-3表达。[ Objective ] To observe the expression of bone morphogenetic protein-2 （BMP-2） and bone morphogenetic protein-3 （BMP-3） in the serum of children in coal-buruing endemic fluorosis areas. [ Methods ] The study enrolled 366 children from two primary schools of Tujing Village （endemic fluorosis area） and 120 children from one primary school of Huaga Village （control area）, Shuicheng County, Liupanshui City, Guizhou Province. All children were 8-14 years old and received a survey on dental fluorosis and urinary fluoride. Based upon informed consent, 115 children in the endemic fluorosis area categorized by dental fluorosis grade and 57 children in the control area were selected for serum sample collection to determine concentrations of serum BMP-2 and BMP-3. [ Results ] The incidence rate of dental fluorosis in the endemic fluorosis area was 61.5% and dental fluorosis was not found in the control children 0f=265.130, P〈 0.05）. The children＇s average urinary fluoride concentration in the fluorosis area [median （P25, PTS）] [0.77（0.536, 1.136）mg/L] was higher （Z=-7.716, P 〈 0.05） than that in the control area [0.49（0.370, 0.660）mg/L] （Z=-7.716, P〈0.05）. The average concentrations [median （P2s, P^s）] of serum BMP-2 and BMP-3 of children in the endemic fluorosis area [16.40（13.51, 27.08）ng/L and 155.39（132.57, 177.95）ng/L, respectively] were lower than those in the control area [18.73（14.89, 25.84）ng/L and 163.67（149.18, 190.74）ng/L, respectively] （ZBMP-2=-2.023, PSMI,-2〈 0.05; Zbmp-3=-2.736, PBMP-3〈 0.01, respectively）. The average concentration of serum BMP-3 in the children of 13-14 age group in the endemic fluorosis area [139.52（122.53, 159.07）ng/L] was lower than that of the children at same age group in the control area [174.05（154.15, 195.03）ng/L] （Z=-2.967, P〈0.01）. No differences were found in serum levels of BMP-3 and BMP-2 among the children in the endemic fluorosis area categorized by dental fluorosis degree （x^2BMP-2=4.6

关 键 词：燃煤型氟中毒 氟斑牙 尿氟 骨形态发生蛋白-2 骨形态发生蛋白-3 儿童 

分 类 号：R179[医药卫生—妇幼卫生保健]