伐地那非降阶梯治疗男性勃起功能障碍的效果分析  

Vardenafil step-down therapy for male erectile dysfunction: a report of 65 cases

作　　者：陈高亮[1] 邓晓洪[1] 欧平[1] 郑军[1] 王元中[1] 李世健[1] 

机构地区：[1]重庆市中山医院泌尿外科,重庆400013

出　　处：《第三军医大学学报》2015年第15期1505-1507,共3页Journal of Third Military Medical University

摘　　要：目的观察逐渐降低伐地那非剂量治疗男性勃起功能障碍(erectile dysfunction,ED)的疗效。方法 65例初治ED患者,分别给予20、10、5 mg(A、B、C 3个阶段)的伐地那非降阶梯序贯疗法,每个阶段治疗时间为1个月。结果 3阶段组患者治疗后国际勃起功能指数(international index of erectile function,IIEF)均高于治疗前(P<0.05)。A、B、C 3阶段患者日记记录插入成功率分别为78.1%、75.9%、69.1%;完成性交的成功率分别为74.9%、70.7%、66.9%,均高于治疗前(P<0.05)。A、B、C 3阶段药物副反应发生率分别为56.9%、29.2%、26.2%,A阶段明显高于B、C阶段(P<0.05)。结论伐地那非减低到中、低剂量时,能够在保证疗效的基础上,显著减少药物副反应的发生。Objective To observe the clinical efficiency of gradually reducing doses of vardenafil for the treatment of male erectile dysfunction. Methods Sixty-five treatment-naive patients with erectile dysfunction admitted in our hospital from January 2011 to June 2014 who received step-down therapy were enrolled in this study. They were given oral vardenafil 20 rag/time （phase A） , 10 mg/time （phase B） , and 5 mg/time （phase C）, each phase lasting for one month. Results erectile function （IIEF） of all phases was significantly higher than After the treatment, international index of that before treatment （P 〈 0.05）. Penile penetration success rates of the 3 phases were 78.1%, 75.9%, and 69.1%, respectively. The success rates of sexual intercourse were 74.9%, 70.7%, and 66.9%, which were significantly higher than those before treatment （P 〈0.05）. The rates of drug side effects of the 3 phases were 56.9%, 29.2%, and 26.2%, respectively, and compared with phase B and phase C, phase A had higher drug side effects, with statistically significant difference （P 〈 0.05）. Conclusion Step-down therapy of vardenafil is effective for the treatment of erectile dysfunction with few drug side effects,

关 键 词：伐地那非 男性勃起功能障碍 疗效 副反应 

分 类 号：R698.05[医药卫生—泌尿科学] R969.4[医药卫生—外科学]