具有杀灭钉螺活性的植物源天然产物研究进展  

Research progress on natural products with molluscicide from plants

作　　者：刘席佑 邹峥嵘[1] 

机构地区：[1]江西师范大学生命科学学院江西省亚热带植物资源保护与利用重点实验室,江西南昌330022

出　　处：《中草药》2015年第14期2177-2188,共12页Chinese Traditional and Herbal Drugs

基　　金：国家"十二五"科技支撑项目(2011BAC13B04);国家自然科学基金资助项目(31260082)

摘　　要：钉螺(oncomelania)是日本血吸虫Schistosoma japonicum的唯一中间寄主,是血吸虫病传播过程中不可缺少的环节。目前用于杀灭钉螺的化学药物存在生产成本高、严重污染环境、钉螺耐药性和对非靶体生物的毒性等诸多问题,这使人们将研究兴趣转向从植物中寻找天然灭螺药物。从结构类型、作用机制和构效关系等方面入手,对具有杀灭钉螺活性的植物源天然产物进行归纳总结,以期为新型植物源灭螺剂的开发提供参考。Oncomelania is the only intermediate host of Schistosoma japonicum as well as an indispensable part of schistosomiasis transmission. Now synthetic molluscicides have a lot of problems, such as high cost of production, chemical pollution, drug resistance, and toxicity to non-target body, which makes people＇s interest turn to plants and plant-derived compounds. This paper describes the current existence of chemical snail control methods and biological snail control methods on the view of chemical construction, mechanism of action, and structure-activity relationships of natural extracts with molluscieidal activity, in order to provide the basis for the development of the new plant molluscacide.

关 键 词：植物来源 灭螺活性 天然产物 皂苷类 生物碱类 

分 类 号：R284[医药卫生—中药学] R285[医药卫生—中医学]