天然产物文殊兰新碱的全合成研究  

Total synthesis of the natural product of crinumaquine

作　　者：陈浩[1,2] 叶霁[2] 刘江云[1] 张卫东[1,2] 孙青龑[2] 

机构地区：[1]苏州大学药学院,江苏苏州215123 [2]第二军医大学药学院,上海200433

出　　处：《药学实践杂志》2015年第4期331-333,共3页Journal of Pharmaceutical Practice

基　　金：国家自然科学基金(81230090);上海市重点学科建设项目(B906)

摘　　要：目的开展文殊兰新碱的全合成工作。方法以3,4-亚甲二氧基苯乙胺和2,5-二甲氧基苯乙酸为起始原料,经缩合、环合、还原和氧化等反应。结果与结论完成了文殊兰新碱的全合成,确定了其最佳合成路线,总收率为73%。Objective To complete the synthesis of the natural product of crinumaquine .Methods 3 ,4-methylenedioxy-phenethylamine and 2 ,5-dimthoxyphenylacetic were taken as starting material ,and chemical reactions of condensation ,cyclization ,reduction ,oxidation and other reactions were conducted .Results and Conclusion The optimum synthetic route was deter-minedunder which the final yield rate was 73% .

关 键 词：生物碱 文殊兰新碱 全合成 

分 类 号：R93[医药卫生—生药学]