α-干扰素治疗病毒性肝炎对泪液分泌及泪膜功能影响的临床研究  

Study on the influences of lacrimal secretion and tear film after interferon-alpha therapy in patients with chronic viral hepatitis

作　　者：王晓黎[1] 徐宁[1] 麦淑仪 叶楠[1] 

机构地区：[1]广州市第八人民医院眼科,广东省广州510440

出　　处：《中国基层医药》2015年第14期2169-2171,共3页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的：分析α-干扰素治疗病毒性肝炎对泪液分泌及泪膜功能的影响。方法收集2014年1月至2015年1月就诊广州市第八人民医院眼科且需要行α-干扰素治疗的病毒性肝炎患者60例（乙型肝炎患者30例，丙型肝炎患者30例），以治疗前及开始治疗2个月后作为时间点，进行干眼的相关检查，包括：病史询问、裂隙灯检查、角膜荧光素染色（fluorescent，FL）、泪膜破裂时间（break up time，BUT）及泪液分泌试验（schirmer test）检查。结果60例病毒性肝炎患者中，治疗前患干眼症19例（31．67％），非干眼症41例（68.33％）。在所有干眼病患者中乙型肝炎9例，占47．37％；丙型肝炎10例，占52．63％。乙肝患者α-干扰素治疗前及治疗2个月后FL评分（t＝－5．288，P＜0．05）、BUT检查（t＝5．799，P＜0．05）、schirmer testⅠ试验（t＝5．319，P＜0．05）；丙肝患者α-干扰素治疗前及治疗2个月后FL评分（t＝－9．103，P＜0．05）、BUT检查（t＝5．682，P＜0．05）、schirmer testⅠ试验（t＝4．592，P＜0．05）。乙肝患者α-干扰素治疗前后干眼发病率分别从26．70％上升至53．30％，丙肝患者治疗前后干眼发病率33．30％上升至60．00％。结论病毒性肝炎患者易并发干眼症，α-干扰素治疗病毒性肝炎会引起泪液分泌减少及泪膜功能减退，应引起临床医生的重视。Objective To analyze the influences of lacrimal secretion and tear film after interferon-alpha therapy in patients with chronic viral hepatitis.Methods Sixty patients with chronic viral hepatitis who would accept the interferon-alpha therapy,including 30 cases of hepatitis B and 30 chronic viral hepatitis C,visited our department of ophthalmology and were enrolled in this study.All cases received eye examination,including medical history,slit lamp examination,corneal fluorescein staining （ FL） ,tear film break-up time （ BUT） and schirmer test before inter-feron-alpha therapy and two months after the therapy.Results In the 60 cases of chronic viral hepatitis,there were 19 dry eye cases （31.67%） and 41 non-dry eye cases （68.33%）.In dry eyes group,9 of them （47.37%） were hepatitis B patients and 10 of them were hepatitis C patients （52.63%） .There was significant difference in FL grade （t=-5.288,P〈0.05）,BUT （t=5.799,P〈0.05）,Schirmer Ⅰ（t=5.319,P〈0.05） test in hepatitis B before and two months after interferon-alpha therapy.Statistical significance had been found before and two months after therapy in FL grade （t=-9.103,P〈0.05）,BUT （t=5.682,P〈0.05）,SchirmerⅠtest （t=4.592,P〈0.05）. The incidence of dry eye syndrome in hepatitis B patients increased from 26.70%to 53.30%two months after treated with interferon-alpha,while the incidence of dry eye syndrome in hepatitis C patients increased from 33.30% to 60.00% two months after treated with interferon-alpha.Conclusion Dry eye syndrome is one of common complica-tions in patients with chronic viral hepatitis.Interferon-alpha therapy would influence the lacrimal secretion and dam-age tear film,which increased the dry symptoms in patients.We should pay attention to the side effects of interferon-alpha therapy.

关 键 词：肝炎 病毒性 人 干扰素Α 角结膜炎 干燥性 

分 类 号：R512.6[医药卫生—内科学]