2011-2013年临床分离病原菌分布及耐药性变迁  

Clinical isolated pathogens distribution and drug resistance change from 2011 to 2013

作　　者：刘杨[1,2] 陈丹丹[1,2] 

机构地区：[1]湖北医药学院附属随州医院 [2]随州市中心医院检验科,湖北随州441300

出　　处：《国际检验医学杂志》2015年第14期2000-2001,2004,共3页International Journal of Laboratory Medicine

摘　　要：目的分析该院2011-2013年的细菌分布及耐药性变迁,为临床合理选用抗菌药物提供依据。方法对医院2011-2013年门诊、住院患者各类标本中分离的病原菌进行统计和耐药分析。结果分离率最高前四位分别为大肠埃希菌、铜绿假单胞菌、鲍曼不动杆菌和金黄色葡萄球菌。耐甲氧西林金黄色葡萄球菌（MRSA）的分离率3年分别为52.17%、57.9%和55.52%。结论产超广谱β-内酰胺酶（ELBLs）的大肠埃希氏菌有增高的趋势,第三代头孢以及氨曲南的耐药率也呈上升趋势,碳青霉烯类仍然是肠杆菌科细菌活性最高的药物;糖肽类、利奈唑胺、利福平及莫西沙星等对MRSA始终保持高活性;非发酵菌耐药率较高,需关注多药耐药菌的出现,建议临床在药敏结果指导下合理使用抗菌素。Objective Analysis the bacteria distribution and drug resistance change in our hospital from 2011 to 2013,and provide evidence for clinical rational use of antimicrobial drugs.Methods Isolate all kinds of pathogens from outpatient,inpatient from^2011 to 2013in statistics and the analysis of drug resistance.Results The top four highest separation rates were Escherichia coli,Pseudomonas aeruginosa,Acinetobacter baumannii and Staphylococcus aureus.Methicillin-resistant staphylococcus aureus（MRSA）separation rate of 3years were 52.17%,57.9%,55.52% respectively.Conclusion Production extended spectrumβ-lactamases（ELBLs）of Escherichia coli has a tendency to increase;the third generation cephalosporins and aztreonam resistance rates also show an upward trend,Carbapenems Enterobacteriaceae is still the most active drugs;Glycopeptides,linezolid,moxifloxacin,and rifampicin always maintain a high activity against MRSA;the resistant rates of non-fermenting bacteria is higher,we need to concerned about the emergence of multi-drug resistant.Recommend giving antibiotics under the guidance of susceptibility results.

关 键 词：病原菌 耐药性 抗菌药物 

分 类 号：R446.5[医药卫生—诊断学]