2011-2013年某院肺炎克雷伯菌的分布及耐药性分析  

Distribution and drug resistance of Klebsiella pneumoniae from 2011 to 2013 in a hospital

作　　者：杨小敏[1] 闫卫利[1] 

机构地区：[1]天津中医药大学第二附属医院,天津300150

出　　处：《国际检验医学杂志》2015年第14期2017-2018,共2页International Journal of Laboratory Medicine

基　　金：国家自然科学基金资助项目(81373849)

摘　　要：目的对临床分离的肺炎克雷伯菌(KPN)的分布及耐药情况进行分析,为临床合理用药及控制院内感染提供依据。方法对2011年1月至2013年12月该院的892株KPN进行统计分析。结果超广谱β-内酰胺酶(ESBLs)阳性KPN占标本总量的40.92%,其检出率最高的科室是ICU(46.46%),最高的标本是痰液(43.51%),ESBLs阳性菌株呈多重耐药趋势,该菌无论产ESBLs与否均对亚胺培南、美罗培南、哌拉西林/他唑巴坦、头孢哌酮/舒巴坦最敏感。结论 ESBLs阳性菌株耐药率均高于ESBLs阴性菌株,建议临床根据是否产ESBLs及病程长短合理使用抗菌药物,对多重耐药的发生率以及有效控制医院感染具有重要意义。Objective The distribution and drug resistance of Klebsiella pneumonia isolated from clinical department were analyzed in this article.It will provide evidence for the clinical rational medication and the control of nosocomial infections.Methods In this hospital,892 strains of Klebsiella pneumonia isolated from January 2011 to December 2013 were performed a statistical analysis.Results Among all the samples,the extended spectrumβ-lactamases（ESBLs）positive Klebsiella pneumoniae accounted for 40.92%.The highest detection rate in the all the clinical department is the ICU with a value of 46.46%.The highest detection rate in the sample is the sputum with a value of 43.51%.In addition,the ESBLs positive strains had a trend of multiple drug resistance.The Klebsiella pneumonia was the most sensitive bacteria to imipenem,meropenem,piperacillin/tazobactam and cefoperazone/sulbactam,no matter whether they produced ESBLs or not.Conclusion The resistant rate of ESBLs positive strains is higher than that of ESBLs negative strains.It was recommended to the rational use of antibiotics based on the duration of disease and the products with or without ESBLs.Furthermore,it will be of great importance to reduce the incidence of multiple drug resistance,and to control the hospital infection effectively.

关 键 词：肺炎克雷伯菌 超广谱Β-内酰胺酶 抗菌药 耐药性 

分 类 号：R446.5[医药卫生—诊断学]