儿童患者中常见肠杆菌科细菌药敏分析  

Analysis of bacterial drug susceptibility of common enterobacteriaceae in pediatric patients

作　　者：徐建民 周丽银 

机构地区：[1]云浮市妇幼保健院,广东527300

出　　处：《国际检验医学杂志》2015年第14期2068-2069,2072,共3页International Journal of Laboratory Medicine

摘　　要：目的了解2013-2014年本院儿童患者中常见肠杆菌科的细菌药敏分析及产ESBL的肠杆菌科细菌的流行情况,为今后医院临床合理用药提供参考。方法常规方法分离培养临床病原菌,肠杆菌科菌株分布及其耐药性进行统计分析。结果共分离出常见肠杆菌科细菌530株,其中大肠埃菌占38.87%和肺炎克雷伯菌占32.08%,敏感性最高的抗菌药物为碳青霉烯类;超广谱β-内酰胺酶（ESBLs）阳性的肠杆菌科细菌,大肠埃希菌阳性率为32.04%,肺炎克雷伯菌为20%,两者差异有统计学意义（P〈0.05）。结论儿童肠杆菌科细菌感染中大肠埃菌和肺炎克雷伯菌占主要,两者ESBL导致的耐药问题也日趋严重,应引起重视。碳青霉烯类仍是肠杆菌科细菌最敏感的药物,抗菌药物治疗应依据细菌学指导,选择敏感药物。Objective To summarize the bacterial drug susceptibility of common enterobacteriaceae in pediatric patients and the epidemic status of the extended spectrum beta-lactamases（ESBLs）during 2013 and 2014in our hospital in order to guide the clinical application of antibacterial drugs.Methods Routine methods of isolation and culture were performed and the distribution of enterobacteriaceae with resistance were statistically analyzed with the software.Results A total of 530 isolates were collected in the hospital in which was 32.08% Klebsiella pneumonia and 38.87% Escherichia coli.The most sensitive drug of Enterobacteriaeeae was carbapenems.ESBLs positive rate in Escherichia coli and Klebsiella pneumonia were 32.04%and 20%.The difference was statistically significant（P〈0.05）.Conclusion Escherichia coli and Klebsiella pneumonia were the common enterobacteriaceae in pediatric patients.Carbapenems remained very high activity against Enterobacteriaceae.However,the carbapenems resistance strains have been appeared that should pay attention.Antibiotic therapy should be based on the guidance of bacteriology to select sensitive drugs.

关 键 词：肠杆菌科 抗菌药物 药敏试验 超广谱Β-内酰胺 

分 类 号：R446.5[医药卫生—诊断学]