1-氰基-中氮茚-3-[N-(2-氨基乙基)]甲酰胺的合成及其Cu^2＋荧光探针行为  

Studies on Synthesis of 1-Cyano-indolizine-3-[N-(2-aminoethyl) ]Carboxamide and Its Application as Fluorescent Sensors for Cu^(2+)

作　　者：杨倩[1] 臧欣欣 吴婧[2] 王炳祥[1] 

机构地区：[1]江苏省生物功能材料重点实验室,江苏省生物医药功能材料工程研究中心,南京师范大学化学与材料科学学院,江苏南京210023 [2]中国药科大学国际医药商学院,江苏南京211198

出　　处：《南京师大学报（自然科学版）》2015年第2期65-68,共4页Journal of Nanjing Normal University(Natural Science Edition)

基　　金：2013年地方高校国家级大学生创新创业训练计划项目;江苏省高等学校大学生实践创新训练计划项目

摘　　要：设计合成了1-氰基-中氮茚-3-[N-(2-氨基乙基)]甲酰胺(化合物3).通过IR,1H NMR对其结构进行了表征,测试了其紫外光谱和荧光光谱,研究了其对Cu2+、Zn2+、Ni2+、Co2+、Mg2+、Na+、K+和Ca2+的识别作用,发现Zn2+、Ni2+、Co2+、Mg2+、Na+、K+和Ca2+对化合物3的荧光光谱几乎没有影响,但Cu2+对化合物3有非常强大亲和力,Cu2+可以使化合物3的荧光发射明显猝灭,化合物3在DMSO溶剂中作为铜离子荧光探针,受常见离子干扰较小,对于铜离子有着较高的选择性.We report here the synthesis of 1-cyano-indolizine-3-[N-（ 2-aminoethyl） ]carboxamide（ No. 3 compound） and the study of it as fluorescent probe for Cu^2＋ions. The structure of the compound 3 was determined by IR,1H NMR. Its UV and fluorescence spectra were measured. The influences of eight metal ions such as Cu^2＋,Zn^2＋,Ni^2＋,Co^2＋,Mg^2＋,Na^＋,K^＋and Ca^2＋on its fluorescence property was studied. Spectroscopic study revealed that the compound 3 had rather strong affinity toward Cu^2＋. The specificity of the compound 3 toward Cu^2＋was determined. Nearly no fluorescence intensity changes were observed in emission spectra with Zn^2＋,Ca^2＋,Na^＋,K^＋,Mg^2＋but Ni^2＋and Co^2＋. However,under identical conditions,the study showed fluorescence quenching from Cu^2＋. So we have developed a new fluorescent sensor.It showed high selectivity toward Cu^2＋in DMSO.

关 键 词：1-氰基-中氮茚-3-[N-(2-氨基乙基)]甲酰胺 CU^2+ 荧光探针 

分 类 号：O626[理学—有机化学]