前瞻性3.0TMRI梯度多回波序列参数优化可行性研究  

Feasibility of multiple-echo GRE with parameters optimized protocol at 3.0T MRI

作　　者：黄海波[1] 周亚丽[2] 李致忠[3] 管俊[1] 覃明[1] 

机构地区：[1]解放军第303医院医学影像科,南宁530021 [2]解放军第303医院血液科,南宁530021 [3]广西卫生职业技术学院,南宁530023

出　　处：《磁共振成像》2015年第7期529-534,共6页Chinese Journal of Magnetic Resonance Imaging

基　　金：广西自然科学基金(编号:2014GXNSFBA118187)

摘　　要：目的探讨缩短首回波（MinimumTE，TEmin）及扫描时间（ScanTime，ST）的3．0T梯度多回波序列参数优化可行性。材料与方法在3．0T扫描仪上，优化梯度多回波序列参数作为研究，与常规序列对照，分别扫描MR专用水模（含0～3．2mM氯化锰盐酸混合液小瓶15只）、45例志愿者肝脏（包括重度铁沉积10例和非重度铁沉积35例），记录两序列TEmin和ST并由接受过良好培训的影像医师利用专业软件测算水模、肝T2＋或R2＋值。应用配对样本t检验或两相关样本非参数检验分析组INT2＋值、TEmin和ST差异性，P〈0．05为差异有统计学意义；采用两变量相关分析与曲线拟合探讨水模R2＋与其浓度相关性。结果（1）水模、志愿者肝扫描两序列TEmin和ST组间差异有统计学意义（P=0．000），研究序列TEmin和ST分别为（0．62±0．02）ms、（9．3±0．8）S，与对照序列相比分别减少约53.0％、45．0％；（2）水模或志愿者肝扫描两序列间T2＋差异在非重度铁沉积组无统计学意义（P水模/肝=0．814／0．201），而在重度铁沉积组有统计学差异（P=0．001），研究序列对重度铁沉积肝T2＋检测可信度较高；（3）研究序列、重复及次月扫描水模各小瓶T2＋值三组间差异无统计学意义（P=-0．584），水模心‘与浓度（PhC）高度线性相关（r=0．986，P=0．000），通过直线回归分析，得到PhC与R2＋拟合直线斜率和截距分别为7．008，0．036。结论在一定铁沉积浓度范围内，3．0TMRI梯度多回波优化序列对活体肝扫描具有可行性，并提高重度铁过载检测可信度。Objective： To explore the feasibility of 12-echo GRE with parameter optimized protocol at 3.0 T MR1 by shortening minimum TE （TEmin） and scan time （ST）. Materials and Methods： A MR special model which includes fifteen vials containing 0--3.2 mM manganese chloride in hydrochloric acid solution, 45 volunteer livers of 10 severe and 35 non-severe iron-overloaded patients were included in the study. 12- echo GRE sequence with parameter optimized at 3.0 Tesla unit was performed in our study and conventional protocol was executed in control group. T2＋ or Rf were quantified by a well-trained physician using a CMR tools or combining with EXCEL after MRI, TEmin and ST obtained from these two protocols were recorded respectively as well. Difference of values in T2＋, TEmi,, and ST between the two groups were analyzed with SPSS 16.0 （Paired-Sample t test or Two Related Sample Test）. P〈0.05 has statistic significance. The correlation between R2＋ and phantom concentration （PhC） was analyzed by two-correlative-variable and curve-fitting. Results： Statistic differences were found for TEmin and ST value between the two groups （P=0.000）, TEmin and ST value obtained from study protocol were （0.62±0.02） ms and （9.3±0.8） s, reduced by 53.0%, 45.0% comparing to control groups, respectively. For phantom and non-severe iron deposit livers, no statistic differences were found for T2＋ value between the two groups （Pphantom/liver0.814/0.201）. However, for severe iron deposit group, there was statistic difference between these two groups （P=-0.001）, also quantitative reliability ofT2＋ value from study protocol was much better than control sequence. No statistic difference was found for T2＋ value among study sequence scan on phantoms, protocol repeating and next month scan （P=0.584）. Phantom R2＋ was linearly correlated with its PhC （r=0.986, P=-0.000）. Through the regressions procedure, a slope of 7.008 and an intercept of 0.036 were found. Conclusions： Within a certain ra

关 键 词：磁共振成像 诊断技术和方法 

分 类 号：R445.2[医药卫生—影像医学与核医学]