Tobacco carcinogen NNK-induced lung cancer animal models and associated carcinogenic mechanisms  

作　　者：Guang-Zhe Ge Tian-Rui Xu Ceshi Chen 

机构地区：[1]Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China [2]Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China

出　　处：《Acta Biochimica et Biophysica Sinica》2015年第7期477-487,共11页生物化学与生物物理学报（英文版）

摘　　要：Tobacco usage is a major risk factor in the development, progression, and outcomes for lung cancer. Of the carcinogens associated with lung cancer, tobacco-specific nitrosamines 4-（methylnitrosami- no）-l-（3-pyridyl）-l-butanone （NNK） is among the most potent ones. The oncogenic mechanisms of NNK are not entirely understood, hindering the development of effective strategies for preventing and treating smoking-associated lung cancers. Here, we introduce the NNK-induced lung cancer ani- mal models in different species and its potential mechanisms. Finally, we summarize several chemo- preventive agents developed from these animal models.Tobacco usage is a major risk factor in the development, progression, and outcomes for lung cancer. Of the carcinogens associated with lung cancer, tobacco-specific nitrosamines 4-（methylnitrosami- no）-l-（3-pyridyl）-l-butanone （NNK） is among the most potent ones. The oncogenic mechanisms of NNK are not entirely understood, hindering the development of effective strategies for preventing and treating smoking-associated lung cancers. Here, we introduce the NNK-induced lung cancer ani- mal models in different species and its potential mechanisms. Finally, we summarize several chemo- preventive agents developed from these animal models.

关 键 词：NNK lung cancer oncogenic mechanisms animal model 

分 类 号：S823.2[农业科学—畜牧学] TL75[农业科学—畜牧兽医]