响应面法优化十味盆安颗粒真空带式干燥工艺研究  

Optimization for vacuum belt drying process of Shiwei Penan Granule by using response surface methodology

作　　者：刘长龙[1,2] 李云霄[1,2] 钱俊[1,2] 吴云[1,2] 萧伟[1,2] 

机构地区：[1]江苏康缘药业股份有限公司,江苏连云港222001 [2]中药制药过程新技术国家重点实验室,江苏连云港222001

出　　处：《中草药》2015年第13期1914-1919,共6页Chinese Traditional and Herbal Drugs

基　　金：科学技术部国家重大新药创制项目(2013ZX09402203):现代中药创新集群与数字制药技术平台(负责人:王振中)

摘　　要：目的优选十味盆安颗粒真空带式干燥的最佳工艺。方法在单因素考察的基础上,选择进料速度、加热温度、干燥时间3个主要因素,以干膏含水率、虎杖苷和芍药苷转移率的综合评分响应值,采用响应面法对十味盆安颗粒真空带式干燥工艺进行优选。结果优选的最佳工艺条件为进料速度1.6 kg/h,加热温度105℃,干燥时间104 min,此时干膏平均含水率为2.80%,虎杖苷平均转移率为92.55%,芍药苷平均转移率为94.77%,综合评分为95.35,RSD为0.42%。结论采用响应面法优选的工艺稳定可行,有效成分转移率高,可指导产业化生产。Objective To optimize the vacuum belt drying process of Shiwei Penan Granules. Methods On the base of single factor experiments, feeding rate, heating temperature, and drying time were selected as the main factors, with composite score of moisture content of dry paste, rates of polydatin and paeoniflorin transfer as the response values, response surface methodology was used to optimize the vacuum belt drying process. Results Optimal parameters were as follows： The feeding rate was 1.6 kg/h, heating temperatures was 105 ℃, drying time was 104 min; Under these conditions, moisture content of dry extract was 2.80% on average, the transfer rate ofpolydatin was 92.55%, and the transfer rate of paeoniflorin was 94.77% on average, the composite score was 95.35 on average, RSD = 0.42%. Conclusion The condition optimized by using response surface methodology is stable and reasonable, which could guide industrial production and keep high transfer rate of effective component.

关 键 词：响应面法 真空带式干燥 十味盆安颗粒 虎杖苷 芍药苷 

分 类 号：R283.6[医药卫生—中药学]