急性冠脉综合征患者血小板参数和纤维蛋白原的临床意义  

Clinical significance of detection of platelet parameters and fibrinogen in patients with acute coronary syndrome

作　　者：孟娟[1] 张明霞[1] 施霞[1] 

机构地区：[1]深圳市第三人民医院心血管内科,广东深圳518112

出　　处：《中国热带医学》2015年第7期898-900,共3页China Tropical Medicine

摘　　要：目的探讨急性冠脉综合征(ACS)患者血小板参数和血浆纤维蛋白原(Fib)水平的变化及意义。方法选取ACS患者138例,分为ST段抬高的心肌梗死(STEMI)组和非ST段抬高的急性冠脉综合征(NSTE-ACS)组,选择同期经冠脉造影排除冠心病的患者40例为对照组,检测血小板参数及血浆Fib,血小板计数(PLT)、平均血小板体积(MPV)、血小板体积分布宽度(PDW)、大血小板比率(P-LCR)。结果 STEMI组和NSTE-ACS组的PLT分别为(208.90±57.16)×109/L和(209.65±49.00)×109/L,明显低于对照组(244.83±61.07)×109/L,差异均有统计学意义(P<0.01);MPV分别为(10.83±0.91)fl和(10.78±1.04)fl,明显高于对照组(10.34±0.71)fl,差异均有统计学意义(P<0.05);PDW、P-LCR和Fib与对照组比较,均明显升高,差异均有统计学意义(P<0.01)。结论 ACS患者PLT减低,MPV、PCT、PDW、Fib均升高,血小板参数、Fib在ACS的发生、发展过程中起到一定的作用,联合检测二者水平对ACS的预防、临床筛选和风险评估具有重要的临床意义。Objective To investigate the clinical value of detecting platelet parameters and fibrinogen（Fib）in patientswith acute coronary syndrome（ACS）. Methods The 138 ACS patients were enrolled in this study including ST elevatedmyocardial infarction（STEMI）and non ST elevated ACS（NSTE-ACS）. Moreover,40 patients who were excluded coronarydisease by coronary angiography were served as control. Both serum Fib and platelet parameters including platelet count（PLT）,mean platelet volume（MPV）,platelet distribution width（PDW）,platelet-large cell ratio（P-LCR）were detected by standardmethods. Results The levels of PLT in the STEMI（208.90±57.16）×10^9/L and NSTE-ACS group（209.65±49.00）×10^9/Lwere significant lower than that in the control group（244.83±61.07）×10^9/L（P0.01）;while the levels of MPV in STEMI（10.83±0.91fl）and NSTE-ACS group（10.78±1.04）fl were significant higher than that in the control group（10.34±0.71）fl（P〈0.05）.The levels of PDW,P-LCR and Fib in STEMI and NSTE-ACS group was significant higher than that in the control group（P〈0.01）Conclusion The level of PLT in ACS patients was decreased while that of MPV,PCT,PDW,Fib were increased.Thelevels of platelet and fibrinogen play important role in the occurrence and development of ACS. Combined detection of levels ofplatelet and fibrinogen possesses important clinical significance in prevention, clinical screening and risk assessment of ACS.

关 键 词：急性冠脉综合征 血小板参数 纤维蛋白原 

分 类 号：R541.4[医药卫生—心血管疾病]