空腹血糖受损人群腰围变化与新发糖尿病发病风险的相关性研究  

Correlation between the Waist Circumference and The Onset Risk of Diabetes in Patients with Impaired Fasting Blood Glucose

作　　者：李忠文[1,2] 林锦信 陈志江[1,2] 麦韵屏[1,3] 

机构地区：[1]广东省人民医院 [2]广东医学科学院内分泌科,广东广州510080 [3]广东医学科学院体检中心,广东广州510080

出　　处：《中国医院用药评价与分析》2015年第5期622-624,共3页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:研究空腹血糖受损人群腰围变化与新发糖尿病发病风险的相关性。方法:回顾性分析广东省人民医院2011年10月—2012年10月、2013年10月—2014年10月进行健康体检的人群资料,从中选取符合标准的空腹血糖受损人群640例作为研究对象,按照基线腰围测量值将其分为4组,比较各组人群的糖尿病发病率,并采用多因素Logistic回归分析对腰围变化和新发糖尿病发病风险的相关性进行分析。结果:空腹血糖受损人群的患病率随腰围增加而逐渐升高;男性发病率(14.63%,79/540)低于女性(15.00%,15/100)(P<0.05)。多因素Logistic回归分析结果显示,校正性别、年龄等因素后,第二、三、四分位组较第一分位组的空腹血糖受损发病风险均增大;不同性别校正上述因素后,男性第二、三、四分位组较第一分位组空腹血糖受损发病风险显著增加(P<0.01)。结论:新发糖尿病的发病风险,将随着空腹血糖受损人群腰围的增加而不断加大,且腰围水平为第四分位组可作为空腹血糖受损防控的主要人群。OBJECTIVE：To study the correlation between the waist circumference and the onset risk of diabetes in patients with impaired fasting glucose.METHODS：A retrospective analysis was performed on the data of the patients receiving health examination in Guangdong Provincial Hospital from Oct.2011 to Oct.2012 or from Oct.2013 to Oct. 2014, from which, 640 patients with impaired fasting blood glucose meeting our inclusion criteria were enrolled and assigned to four groups based on the baseline waist circumference.The incidence of diabetes was compared among the four groups, and the relationship between waist circumference and onset risk of diabetes was analyzed using multivariate logistic regression analysis.RESULTS：The incidence of diabetes in patients with impaired fasting glucose increased accompanied with the increase of their waist circumference;the incidence rate of diabetes was lower for men （14.63%, 79/540 ） than for women （ 15.00%, 15/100 ） （ P 〈0.05 ） .Multivariate Logistic regression analysis showed that after adjusting gender, age and other factors, the risk of impaired fasting glucose in the second, third and fourth quartile groups was higher than in the first quartile group （ P 〈0.01 ）; after adjusting the above factors for patients of different gender, the risk of impaired fasting glucose was higher in the second and third quartile male groups than in the first quartile male group （P〈0.01）.CONCLUSIONS：The risk of new onset of diabetes increases with the increasing of waist circumference in patients with impaired fasting glucose, and the forth quartile group in terms of waist circumference level can be taken as the target population with regard to impaired fasting glucose control.

关 键 词：空腹血糖受损 腰围 新发糖尿病 发病风险 相关性 

分 类 号：R977.15[医药卫生—药品]