丁苯酞氯化钠注射液与甲磺酸倍他司汀联合治疗椎-基底动脉供血不足的临床研究  

Butylphthalide and Sodium Chloride Injection plus Betahistine Mesylate in Treatment of Vertebrobasilar Insufficiency: A Clinical Study

作　　者：陈敏[1] 徐菁[2] 何万珍[3] 周长胜[4] 

机构地区：[1]湖北医药学院附属十堰市太和医院武当山分院药剂科,湖北丹江口442714 [2]湖北医药学院附属东风公司医院药剂科,湖北十堰442008 [3]湖北医药学院附属十堰市太和医院武当山分院口腔科,湖北丹江口442714 [4]湖北中医药大学附属十堰市中医医院心脑血管科,湖北十堰442012

出　　处：《中国医院用药评价与分析》2015年第6期721-724,共4页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的：观察丁苯酞氯化钠注射液与甲磺酸倍他司汀联合治疗椎-基底动脉供血不足的临床疗效。方法：选择椎-基底动脉供血不足患者128例,经给予安慰剂洗脱2周后随机分为观察组和对照组,每组64例。观察组在常规治疗基础上给予丁苯酞氯化钠注射液200 ml/d、甲磺酸倍他司汀18-36 mg/d;对照组在常规治疗基础上给予甲磺酸倍他司汀18-36 mg/d;疗程均为2周。分别在用药前、用药后14 d观察患者临床疗效,血清内皮素（ET）、一氧化氮（NO）、不对称二甲基精氨酸（ADMA）水平,血液流变学指标（全血比黏度、血浆比黏度、血细胞比容、红细胞聚集指数）,双侧椎-基底动脉血流平均流速（Vm）和收缩峰值（Vs）等指标的改善情况。结果：治疗后2组患者临床疗效,血清ET、NO、ADMA水平,血液流变学,双侧椎基底动脉Vm、Vs等指标的改善程度与用药前比较差异均具有统计学意义（P〈0.05）,且观察组明显优于对照组,差异均具有统计学意义（P〈0.05）。结论：丁苯酞氯化钠注射液联合甲磺酸倍他司汀治疗椎-基底动脉供血不足临床疗效确切,可显著改善血管内皮功能、血液流变学和椎基底动脉血流速度,预防脑卒中的发生,值得临床推广应用。OBJECTIVE：To evaluate the clinical efficacy of butylphthalide and sodium chloride injection plus betahistine mesylate in the treatment of vertebrobasilar insufficiency.METHODS： 128 patients with vertebrobasilar insufficiency were selected and given placebo elution for 2 weeks before being randomly divided into observation group and control group, of 64 cases each.The observation group received conventional treatment plus butylphthalide and sodium chloride injection （200 ml/d） and betahistine mesylate （18-36 mg/d） for two weeks, while the control group received conventional treatment plus betahistine mesylate （18-36 mg/d） for 2 weeks.Serum levels of ET, NO and ADMA and blood rheology indexes （ whole blood viscosity, plasma viscosity, red blood cell hematocrit and erythrocyte aggregation index） , bilateral vertebral-basilar artery blood flow mean velocity（ VM） and systolic peak velocity （ VS） index before and after medication （ 0 and 14 days ） were measured.RESULTS： The differences before and after treatment of 14 days in clinical efficacy, serum ET, NO and ADMA levels, blood rheology, bilateral vertebral-basilar artery blood flow mean velocity （ VM ） and systolic peak velocity （ VS ） indexes in the two groups were statistically significant （P〈0.05）, with observation group showing significantly better improvement than in the control group, and the differences between the two groups were statistically significant （ P 〈0.05 ） .CONCLUSIONS： Treatment of vertebrobasilar insufficiency with butylphthalide and sodium chloride injection plus betahistine mesylate resulted in confirmed efficacy in that which can significantly improve endothelial function, blood rheology and vertebral basilar artery blood flow velocity and prevent cerebral stroke, the use of which thus is worthy of clinical recommendation.

关 键 词：椎底动脉供血不足/药物疗法 甲磺酸盐类 倍他司汀 血液流变学 丁苯酞氯化钠注射液 

分 类 号：R543.5[医药卫生—心血管疾病] R969.4[医药卫生—内科学]