普鲁卡因静脉封闭治疗顽固瘙痒症的疗效观察  

Efficacy of Intravenous Procaine Block Therapy for Intractable Pruritus

作　　者：吴定苏 林乐泓 詹美伶 练思玉 李晓英 

机构地区：[1]东莞市莞城人民医院皮肤科,广东东莞523900 [2]东莞市莞城人民医院外科,广东东莞523900 [3]东莞市莞城人民医院功能科,广东东莞523900

出　　处：《中国医院用药评价与分析》2015年第6期740-742,共3页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:探讨普鲁卡因静脉封闭治疗顽固瘙痒症的临床效果。方法:将168例顽固性皮肤瘙痒症患者按照随机数字抽签方法分为2组,对照组患者给予常规治疗,观察组患者在此基础上加用普鲁卡因静脉封闭治疗,对比2组患者的治疗效果。结果:观察组患者临床症状改善时间显著短于对照组,差异有统计学意义(P<0.01);2组患者总有效率的差异无统计学意义(P>0.05),但观察组患者显效率显著大于对照组(P<0.05)。治疗期间2组患者均未见明显不良反应。结论:在常规治疗的基础上应用普鲁卡因静脉封闭治疗顽固瘙痒症,能从瘙痒的产生和传递环节同时给予干预,从而达到更好的治疗效果,对于改善患者病情具有积极意义。OBJECTIVE：To evaluate the clinical efficacy of intravenous procaine block therapy for intractable pruritus.METHODS：168 patients with intractable pruritus patients were randomly divided into two groups, with the patients in the control group received conventional therapy alone, while the patients in the observation group were treated with add-on intravenous procaine block therapy, with therapeutic efficacy compared between the two groups.RESULTS：The observation group showed significantly earlier improvement in clinical symptoms than in the control group and the difference was statistically significant （ P〈0.01）;the differences in the total effective rate between the two groups were of no statistical significance （P 〉0.05）;however, the markedly effective rate was significantly higher in the observation group than in the control group （P〈0.05）.During the treatment, significant adverse reactions were noted in none of the patients in the 2 groups.CONCLUSIONS： Addition of intravenous procaine block therapy to the conventional therapy resulted in better therapeutic efficacy in the treatment of intractable pruritus due to the intervention on the production and transmission of itching, which thus has positive meaning for improving patient＇s condition.

关 键 词：顽固瘙痒症 普鲁卡因 马来酸氯苯那敏 

分 类 号：R986[医药卫生—药品]