黄芪注射液与灯盏花素注射液联合治疗糖尿病肾病的临床观察  

Efficacy of Astragalus Injection plus Breviscapine Injection for Diabetic Nephropathy

作　　者：谢琼[1] 卢月月[2] 易宏锋[3] 

机构地区：[1]荆州市第一人民医院内分泌一科,湖北荆州434000 [2]荆州市第一人民医院消化二科,湖北荆州434000 [3]荆州市第一人民医院消化一科,湖北荆州434000

出　　处：《中国医院用药评价与分析》2015年第6期751-753,共3页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:探讨黄芪注射液与灯盏花素注射液联合治疗糖尿病肾病的临床疗效。方法:纳入2012年1月—2013年1月收治的80例糖尿病肾病患者,以随机数字表法分为观察组和对照组各40例。2组患者均接受常规治疗,观察组患者加用黄芪注射液与灯盏花素注射液联合治疗,对照组加用黄芪注射液治疗,观察2组患者的临床疗效。结果:观察组患者的总有效率为87.50%(35/40),对照组为75.00%(30/40),2组差异有统计学意义(P<0.05);观察组患者血尿素氮、尿清蛋白排泄率、血清肌酐等指标改善情况明显优于对照组,差异有统计学意义(P<0.05);2组患者空腹血糖水平比较,差异无统计学意义(P>0.05);2组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论:在糖尿病肾病的常规治疗基础上,加用黄芪注射液与灯盏花素注射液,有利于改善临床症状,不良反应少,安全、可靠,临床疗效优于加用黄芪注射液单药治疗,值得临床推广。OBJECTIVE：To evaluate the clinical efficacy of astragalus injection plus breviscapine injection in treatment of diabetic nephropathy.METHODS：A total of 80 patients with diabetic nephropathy patients treated in our hospital from Jan.2012 to Jan.2013 were randomly divided into observation group and control group of 40 cases each. The observation group received routine therapy plus astragalus injection and Breviscapine injection while the control group received routine therapy plus astragalus injection alone.The clinical efficacy of the 2 groups was evaluated. RESUTLS： The effective rate was 87.50%（ 35/40 ） for observation group vs.75%（ 30/40 ） for control group, showing significant difference between 2 groups （ P〈0.05 ） .The observation group had better improvement than did the control group in blood urea nitrogen （ BUN） , urinary albumin excretion rate（ UAER） , serum creatinine and other indicators（P〈0.05）;there were no statistically significant difference in FBG levels and the incidence of adverse drug reactions between the two groups （ P 〉0.05 ） .CONCLUSIONS： Addition of astragalus injection and breviscapine injection to the routine therapy in treatment of diabetic nephropathy resulted in improvement in clinical symptoms, few adverse reaction, good safety and reliability, with better clinical efficacy than the addition of astragalus injection alone, thus the clinical use of astragalus injection and breviscapine injection added to the routine therapy in treatment of diabetic nephropathy is worthy of clinical recommendation.

关 键 词：糖尿病肾病 黄芪注射液 灯盏花素注射液 临床疗效 

分 类 号：R932[医药卫生—生药学]