A facile access for the C–N bond formation by transition metal-free oxidative coupling of benzylic C–H bonds and amides  

作　　者：Jie Liu Heng Zhang Hong Yi Chao Liu Aiwen Lei 

机构地区：[1]College of Chemistry and Molecular Sciences, Wuhan University [2]National Research Centre for Carbohydrate Synthesis, Jiangxi Normal University

出　　处：《Science China Chemistry》2015年第8期1323-1328,共6页中国科学（化学英文版）

基　　金：supported by the National Basic Research Program of China(2011CB808600,2012CB725302);the National Natural Science Foundation of China(21390400,21272180,21302148);the Research Fund for the Doctoral Program of Higher Education of China(20120141130002);the Program for Changjiang Scholars and Innovative Research Team in University(IRT1030);The Program of Introducing Talents of Discipline to Universities of China(111 Program)is also appreciated

摘　　要：Using 2,3-dichloro-5,6-dicyano-p-benzoquinone(DDQ)as the oxidant,we communicate an efficient oxidative C–N coupling of benzylic C–H bonds with amides to afford a series of amination products in good yields.A wide range of functional groups as well as various sulfonamides and carboxamides are well tolerated.Moreover,this reaction involves both the challenging C–H functionalization and C–N bond formation.Using 2,3-dichloro-5,6-dicyano-p-benzoquinone （DDQ） as the oxidant, we communicate an efficient oxidative C-N coupling of benzylic C-H bonds with amides to afford a series of amination products in good yields. A wide range of functional groups as well as various sulfonamides and carboxamides are well tolerated. Moreover, this reaction involves both the challenging C-H functionalization and C-N bond formation.

关 键 词：oxidative coupling C-N bond formation AMINATION C-H functionalization 

分 类 号：O621.25[理学—有机化学]