不同胰岛素给药方法治疗急诊糖尿病酮症酸中毒的临床研究  

Different Insulin Delivery Methods of Clinical Study on the Treatment of Diabetic Ketoacidosis

作　　者：岑斌[1] 

机构地区：[1]简阳市人民医院重症监护室,四川简阳641400

出　　处：《糖尿病新世界》2015年第10期67-68,共2页Diabetes New World Magazine

摘　　要：目的对比两种不同胰岛素给药方法治疗急诊尿病酮症酸中毒(DKA)患者的临床疗效。方法选取2012年6月—2014年6月该院收治的120例急诊DKA患者,所有患者经临床采取《内科学》标准诊断确诊为DKA,随机将两组患者分为观察组和对照组,两组患者均采取抗炎、纠正水电解质紊乱、补充扩容、营养支持等对症治疗,对照组在对症治疗的基础上,采取小剂量胰岛素对患者持续静脉滴注;观察组患者在对症治疗基础上采用胰岛素泵对患者进行持续的皮下胰岛素输注,对比两组患者的临床效果。结果治疗前后两组患者空腹血糖(mmol/L),差异无统计学意义(P>0.05);低血糖发生例数(n)、血糖达标时间(h)、尿酮体转阴时间(h)与胰岛素用量(U)差异均有统计学意义(P<0.05)。结论采用胰岛素泵为患者持续皮下输注胰岛素能够有效降低患者低血糖发生率,减少胰岛素使用量,实现更好的血糖控制效果,同时基础用药与餐食用药相结合,可以进一步稳定患者的胰岛素水平,严格控制患者血糖,可进行临床广泛推广应用。Objective To compare the two different insulin delivery methods for clinical effect of DKA. Methods Selected June 2012-June 2014 I homes admitted of 120 cases DKA patients, all patients in clinical diagnosed by science standard confirmed as DKA, two groups of patients were divided into observation group and control group, two groups of patients were treated by anti-inflammatory, and corrected hydropower solutions mass disorder, and added expansion, and nutrition support, symptomatic treatment.Based on control group in symptomatic treatment,the patients in observation group were symptomatic treatment based on the use of insulin pump on patients with subcutaneous insulin continuous infusion, clinical effect were compared between two groups. Results the two groups before and after treatment in patients with fasting blood glucose（mmol/L）（P〉0.05）.There was no statistical significance; hypoglycemia cases（n）, blood glucose（H）, the time of ketonuria time（H） and insulin dosage（U）（P〈0.05） had statistical significance. ConclusionContinuous subcutaneous insulin infusion treament can rapidly correct metabolic disorder of patients with diabetic ketoacidosis, it can reduce the risk of hypoglycemia and insulin dosage, the clinical curative effect is remarkable, it is worth to popularize.

关 键 词：胰岛素泵 持续皮下输注胰岛素 糖尿病酮症酸中毒 

分 类 号：R587.2[医药卫生—内分泌]