碱性成纤维细胞生长因子促进神经损伤修复的研究进展  

The Development of the Study on bFGF Promote the Nerve Injury Repair

作　　者：张超[1] 项丽娜[1] 陈德培[1] 吕鑫鑫[1] 赵宜桐 王璐瑶[1] 肖健[1,2] 张宏宇[1,2] 

机构地区：[1]温州医科大学药学院,温州325035 [2]浙江省生物技术制药工程重点实验室,温州325035

出　　处：《中国生物工程杂志》2015年第6期75-79,共5页China Biotechnology

基　　金：国家自然科学基金资助项目(81200958;81472165)

摘　　要：碱性成纤维细胞生长因子(basic fibroblast growth factor,b FGF)是成纤维细胞生长因子家族(FGFs)的成员之一。它是哺乳动物和人体中一种非常微量的活性物质,因其具有广泛的生理功能和重要的临床应用价值受到了国内外学者的高度重视。b FGF生物活性的多效性以及神经营养的广谱性,为其从基础走向临床提供了保证。而b FGF如何发挥神经损伤修复作用的功能和机制,仍有待进一步的发现及研究,这也是目前国内外探索和开发b FGF新临床药物的研究热点之一。针对b FGF的生物学特点及其在神经损伤修复中的功能,特别是在中枢神经系统和外周神经系统疾病中的研究进展进行了综述。Basic fibroblast growth factor（ b FGF） is part of the fibroblast growth factor（ FGFs） family. b FGF is unique in that it is expressed both in the animal and human model but has also garnered attention for its extensive physiological functions and important clinical applications. Current evidence suggests that b FGF may play a prominent role in nerve cell regeneration,due to its pluripotent effects and neurotrophic action. Although it is already extensively studied in various disease states,there still remains much to be discovered about the functions and mechanisms in nerve regeneration of b FGF. The following review summarizes the current knowledge on b FGF with a special emphasis on central nervous system and peripheral nervous system disease.

关 键 词：碱性成纤维细胞生长因子 神经损伤 修复 信号通路 

分 类 号：Q819[生物学—生物工程]