老年高血压患者MMP-9、脂联素及踝臂指数与肥胖的关系  

Study on the relationships between obesity and MMP-9, adiponectin, ankle brachial index

作　　者：楚轶[1] 冯品[1] 任引刚[1] 芦芗平 

机构地区：[1]第四军医大学唐都医院心内科,陕西省西安市710038

出　　处：《中国心血管病研究》2015年第7期652-655,共4页Chinese Journal of Cardiovascular Research

摘　　要：目的研究老年原发性高血压患者血清基质金属蛋白酶-9（MMP-9）、脂联素（ADP）水平及踝臂指数（ABI）的变化与肥胖的关系。方法将入选的高血压患者分为高血压肥胖组和单纯高血压组，正常血压者分为单纯肥胖组和正常对照组。四组均采用ELISA法测定MMP-9及ADP，并测量ABI。比较四组MMP-9、ADP和ABI水平。结果①单纯高血压组、单纯肥胖组、高血压肥胖组的BMI、LDL—C均较对照组升高（P〈0．05）；单纯高血压组、高血压肥胖组的FPG、SBP、DBP均较对照组增高（P〈0．05）；单纯高血压组、高血压肥胖组的SBP、DBP、FPG较单纯肥胖组增高（P〈0．05）；单纯肥胖组、高血压肥胖组的BMI、TG、TC、LDL—C较单纯高血压组增高（P〈0．05）。②对照组、单纯高血压组、单纯肥胖组和高血压肥胖组MMP-9、ADP及ABI依次增高或降低，且单纯高血压组、单纯肥胖组、高血压肥胖组和对照组比较，单纯肥胖组、高血压肥胖组和单纯高血压组比较，高血压肥胖组和单纯肥胖组比较，差异均有统计学意义（P〈0．05）。③多元线性回归分析显示，MMP-9与SBP、LDL呈正相关，ADP与SBP、DBP、BMI呈负相关，ABI与SBP、DBP、TG呈负相关。结论MMP-9、ADP、ABI在高血压、肥胖及动脉粥样硬化进程中有重要意义，对临床疾病评估有-定指导意义。Objective To investigate the relationship between MMP-9, ADP, ABI and obesity in elderly patients with hypertension. Methods All subjects were classified as control group, simple obesity group, simple hypertension group and obesity-associated hypertension group. Serum concentrations of MMP-9 and ADP levels were measured by the Elisa method. ABI was also measured. Results （1）BMI, LDL-C in control group, simple obesity group, simple hypertension group and obesity-associated hypertension group, were increased gradually, and compare each of them there were statistical significance （P〈O.05）. FPG, SBP, I）BP in simple hypertension group and obesity-associated hypertension group higher than control group, and compare each of them there were statistical significance （P〈0.05）, BMI, TG, TC, LDL-C in simple obesity group and obesity associated hyperten- sion group higher than simple hypertension group, and compare each of them there were statistical significance（P〈 0.05）. （2）Serum MMP-9, ADP and ABI concentrations in control group, simple hypertension group, simple obesi- ty group, and obesity-associated hypertension group, were increased or decreased gradually, and compare each of them there were statistical significance（P〈0.05）.（3）Muhipleregression analysis showed that MMP-9 was positively correlated with SBP, LDL. ADP was negatively correlated with SBP, DBP, BMI. ABI was negatively correlated with SBP, DBP, TG. Conclusion MMP-9, ADP and ABI play very important role in the process of obesity and atherosclerosis and also can accelerate atherosclerosis. It＇s meaningful to clinical evaluation.

关 键 词：高血压 肥胖 血清基质金属蛋白酶-9 脂联素 踝臂指数 

分 类 号：R544.1[医药卫生—心血管疾病]