血清蛋白电泳在肝移植术后功能及并发症监测中的应用  

The application of serum protein electrophoresis in monitoring the function recovery and complications after liver transplantation

作　　者：陈立[1] 肖萍[1] 赵志恒[1] 张维强[1] 穆红[1] 

机构地区：[1]天津市第一中心医院检验科,天津市300192

出　　处：《实用检验医师杂志》2015年第2期94-96,共3页Chinese Journal of Clinical Pathologist

基　　金：国家临床重点专科建设项目(检验专业)经费资助国卫办医函(2013)544号

摘　　要：目的探讨血清蛋白电泳用于肝脏移植术后肝脏功能恢复及并发症监测中的临床应用价值。方法选取我院2013年3月至2013年6月期间接受肝移植手术的患者33例,检测受试者首次就诊及肝移植术后约1年时血清蛋白电泳各组分,分析移植前后各蛋白组分含量及异常蛋白的出现情况。结果肝脏移植后白蛋白组分含量明显高于移植前,而γ球蛋白组分含量低于移植前,且差异均有统计学意义(P均<0.05)。α1、α2、β蛋白组分含量移植前后差异均无统计学意义(P均>0.05)。移植前有9例谱带呈现β-γ桥;移植后γ球蛋白异常升高例数明显低于移植前,另有2例出现寡克隆带。结论分析肝脏移植患者血清蛋白电泳各成分变化可以监测移植后肝脏合成功能恢复及是否出现并发症。Objective To analyze the application value of serum protein electrophoresis for monitoring liver function recovery and complications after liver transplantation. Methods 33 cases of liver transplantation patients in our hospital from March 2013 to June 2013 were collected. Serum protein electrophoresis components of the patients were analyzed when first admission and about one year after transplantation. The protein constituent content and abnormal protein before and after transplantation were analyzed. Results Compared with pretransplant group, the albumin was higher, and γ-globulin component was lower significantly in post transplant group, and the differences all had statistical significance（Pall〈 0.05）. There were no statistical significance in the differences of α1, α2and β protein constituent content between pretransplant group and post transplant group. β-γ bridge was detected in 9 cases in pretransplant group. While the cases with abnormal γ-globulin component in post transplant group was less than that of pretransplant group, in which oligoclonal bands were detected in 2 cases. Conclusion The protein component analysis before and after transplantation by serum protein electrophoresis can monitor liver function recovery and complications of the liver transplantation patients.

关 键 词：血清蛋白电泳 肝脏移植 肝功能 并发症 

分 类 号：R657.3[医药卫生—外科学] R446.6[医药卫生—临床医学]