代谢综合征与肿瘤相关性流行病学调查  

Epidemiological study of relationship between metabolic syndrome and cancers

作　　者：赵思文[1] 吴君洁[1] 冯婥[1] 张小明[1] 

机构地区：[1]广州医科大学附属第二医院健康体检中心,广东广州510260

出　　处：《分子诊断与治疗杂志》2015年第4期257-260,265,共5页Journal of Molecular Diagnostics and Therapy

基　　金：广州市卫生局科研资助项目(20151A010100)

摘　　要：目的筛查恶性肿瘤,为其病因、发病机制和预防提供科学依据。方法从2013年1月至2014年12月期间在我院体检人群中随机抽取6 050例,年龄在20岁~80岁之间,平均年龄（53.0±3.4）岁。其中男3 826例,女2 224例,男女比为1.7∶l。按代谢综合征（metaholic syndrome,MS）诊断标准分为MS组与非MS组,MS组再分为肿瘤组与非肿瘤组,比较两对应组间MS各组分的数据,分析MS各组分与肿瘤发生的相关性。结果符合MS诊断标准986人,患病率为16.3%（986/6 050）。发现肿瘤患者43人,占MS人群4.36%（43/986）。肿瘤组MS各组分明显高于非肿瘤组（P〈0.05）。腰围、甘油三脂（triglyceride,TG）、高密度脂蛋白胆固醇（high density lipoprotein cholesterol,HDL-C）和空腹血糖（fasting plasma glucose,FPG）与肿瘤相关（P〈0.01）,其中腰围、TG、和FPG是肿瘤的危险因素,HDL-C是保护因素。结论伴发MS组分可能与肿瘤发展相关。Objective To provide scientific basis for pathogenesis, mechanism and prevention of related cancers by screening cancers among MS patients. Methods 6 050 physical examination persons[ranged from 20 to 80 in age（mean 53.0 ±3.4 years old）] were selected randomly in our physical examination center from January 2013 to December 2014. Cases were divided into MS group and non-MS group at random according to the criterion of MS. The MS group was divided into cancer group and non-cancer group. MS components in MS group and non-MS group, cancer group and non-cancer group were compared,respectively. And the correlation between cancers and components of MS was evaluated by linear logistic regression analysis. Results 986 persons among 6 050 physical examination persons were diagnosed with MS, with the morbidity of 16.3%（986/6 050）. 43 persons were diagnosed with cancer, with the morbidity in MS patients of 4.36%（43/986）. The measuved values of each component in MS group were higher than those in non-MS group（P 0.05）. Logistic regression analysis showed that waist circumference, triglyceride（TG）, high density lipoprotein cholesterol（HDL-C） and fasting plasma glucose（FPG） were correlated with cancers.Waist circumference, TG, and FPG were risk factors for cancer, while HDL-C was a protective factor. Conclusion Concomitant MS components maybe associated with the development of cancers.

关 键 词：代谢综合征 肿瘤 流行病学调查 

分 类 号：R589[医药卫生—内分泌] R73-31[医药卫生—内科学]