孕期妇女经职业接触全氟化合物对妊娠结局的影响  

Effect of occupational exposure to perfluorinated compounds during pregnancy on pregnancy outcome

作　　者：孙林[1] 邓冰[1] 张琦豪[1] 范霞林 李虹[1] 王加好[1] 

机构地区：[1]贵阳医学院医学心理学教研室,贵州贵阳550004

出　　处：《中国妇幼保健》2015年第22期3773-3775,共3页Maternal and Child Health Care of China

基　　金：国家自然科学基金项目〔81260429〕;贵州省科技厅攻关项目〔黔科合SY字(2012)3128〕

摘　　要：目的 探讨孕期妇女职业接触全氟化合物（PFCs）与不良妊娠结局之间的关联性,为生殖健康及妇幼保健工作提供参考依据。方法 选取2013年1-11月在贵阳医学院附属医院产前诊断中心进行产检的孕产妇640例,对其进行问卷调查,了解其在孕期经职业接触PFCs的相关信息以及妊娠结局情况。结果 孕产妇是否发生不良妊娠结局在从事服装、皮革、家具防污剂、涂料装修、印刷品、纸质包装职业方面比较,差异有统计学意义（P〈0.05）;而在从事地毯、合成洗涤剂、防水材料职业方面比较,差异无统计学意义（P〉0.05）。Logistic回归分析结果显示,从事服装（OR=3.131）、印刷（OR=3.495）职业是不良妊娠结局的危险因素,其他因素与不良妊娠结局均无关（P〉0.05）。结论 孕期女性应尽量避免从事与PFCs有关的职业,同时相关部门应重视PFCs的危险性,尽量减少PFCs的污染,降低不良妊娠结局的发生率。Objective To explore the correlation between occupational exposure to perfluorinated compounds（ PFCs） during pregnancy and adverse pregnancy outcome,provide reference for reproductive health and maternal and child health care work. Methods A total of 640 pregnant women receiving prenatal examination in Center of Prenatal Diagnosis in Affiliated Hospital of Guiyang Medical College from January to November in 2013 were selected,a questionnaire survey was conducted to understand the related information about occupational exposure to PFCs during pregnancy and pregnancy outcome. Results There was statistically significant difference in adverse pregnancy outcome among the pregnant women engaged in garment,leather,furniture antifouling agents,paint decoration,print,paper packaging careers（ P〈0. 05）; there was no statistically significant difference in adverse pregnancy outcome among the pregnant women engaged in carpets,synthetic detergent,and waterproof material careers（ P〉0. 05）. Logistic regression analysis showed that garment（ OR = 3. 131） and print careers（ OR = 3. 495） were risk factors of adverse pregnancy outcome,the other factors were not correlated with adverse pregnancy outcome（ P〉0. 05）. Conclusion Pregnant women should avoid engaging in PFCs related careers,while the relevant departments should pay attention to the danger of PFCs,minimize PFCs pollution and reduce the incidence rate of adverse pregnancy outcome.

关 键 词：全氟化合物 职业接触 不良妊娠结局 危险因素 

分 类 号：R173[医药卫生—妇幼卫生保健]