Fast reconstruction in fluorescence molecular tomography using data compression of intra- and inter-projections  

作　　者：张久楼 时军威 左思敏 刘飞 白净 罗建文 

机构地区：[1]Department of Biomedical Engineering, School of Medicine, Tsinghua University [2]Tsinghua-Peking Center for Life Sciences [3]Center for Biomedical Imaging Research, Tsinghua University

出　　处：《Chinese Optics Letters》2015年第7期52-56,共5页中国光学快报（英文版）

基　　金：supported by the National Basic Research Program of China(No.2011CB707701);the National Natural Science Foundation of China(Nos.81227901,81271617,61322101,61361160418,and 61401246);the National Major Scientific Instrument and Equipment Development Project(No.2011YQ030114);the China Postdoctoral Science Foundation(No.2014M550073);supported in part by the Postdoctoral Fellowship of TsinghuaPeking Center for Life Sciences

摘　　要：In order to improve the reconstruction accuracy in fluorescence molecular tomography （FMT）, a common ap- proach is to increase the number of fluorescence data or projections. However, this approach consumes too much memory space and computational time. In this Letter, a data compression strategy that involves the removal of the redundant information from both intra- and inter-projections is proposed to reduce the dimension of the FMT inverse problem. The performance of this strategy is tested with phantom and in vivo mouse experiments. The results demonstrate that the proposed data compression strategy can accelerate the FMT reconstruction nearly tenfold and almost without any quality degradation.In order to improve the reconstruction accuracy in fluorescence molecular tomography （FMT）, a common ap- proach is to increase the number of fluorescence data or projections. However, this approach consumes too much memory space and computational time. In this Letter, a data compression strategy that involves the removal of the redundant information from both intra- and inter-projections is proposed to reduce the dimension of the FMT inverse problem. The performance of this strategy is tested with phantom and in vivo mouse experiments. The results demonstrate that the proposed data compression strategy can accelerate the FMT reconstruction nearly tenfold and almost without any quality degradation.

关 键 词：FLUORESCENCE Inverse problems TOMOGRAPHY 

分 类 号：O561[理学—原子与分子物理]