垂盆草总黄酮对实验性肝纤维化干预作用的研究  

Study on Intervention Effects of Sedum Sarmentosum Total Flavanones against Experimental Hepatic Fibrosis

作　　者：林远灿[1] 骆海莺[2] 

机构地区：[1]浙江中医药大学附属第一医院,浙江杭州310006 [2]南京军区杭州疗养院,浙江杭州310007

出　　处：《中华中医药学刊》2015年第8期1962-1964,I0018,I0019,共5页Chinese Archives of Traditional Chinese Medicine

基　　金：浙江省自然科学基金项目(LQ15H290001);浙江中医药大学科研基金项目(2014ZY08)

摘　　要：目的:研究垂盆草总黄酮(SSTF)对实验性大鼠肝纤维化的防治作用。方法:SD大鼠随机分为正常对照组、模型组、100、200和400 mg·kg-1SSTF组、秋水仙碱阳性药对照组,采用四氯化碳诱导大鼠肝纤维化模型,造模后,分别给予给药组相应的受试药物,给予正常对常组和模型组生理盐水。观察SSTF对肝纤维化大鼠血清中丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、透明质酸(HA)、层黏蛋白(LN)水平,肝脏病理组织学及肝组织中胶原增生程度的影响。结果:SSTF 100、200和400 mg·kg-1组及秋水仙碱组肝纤维化大鼠血清ALT、AST及HA、LN的含量能明显降低,肝组织炎症活动度及肝纤维化程度改善。结论:SSTF有明显的抗肝细胞损伤、促进肝功能恢复的作用,对大鼠实验性肝纤维化具有较好的防治作用。Objective ：To study the preventive effect of Sedum Sarmentosum total flavonoids （SSTF） on hepatic fibrosis in rats. Methods：SD rats were randomly divided into normal control group, model group, 100,200 and 400 mg/kg SSTF groups and colchicine positive control group. Bat liver fibrosis model was induced by CC14. After modeling, the treatment groups were given the appropriate drugs and normal saline for normal and model groups. The effects of SSTF on the levels of serum ALT,AST ,HA,LN in rats with liver fibrosis and histopathological changes as well as collagen hyperplasia formation in liver tissue were observed. Results：SSTF 100,200 and 400 mg/kg and colchicine groups serum ALT, AST and HA, LN contents can be significantly reduced and the liver inflammation and liver fibrosis were relieved. Conclusion： SSTF has significant functions of anti - liver cell damage and promoting liver function recovery and on experimental hepatic fibrosis in rats it has good control effect.

关 键 词：垂盆草总黄酮 肝纤维化 

分 类 号：R285.5[医药卫生—中药学]