高温对人脑执行功能影响的 fMRI 研究  

fMRI study on the impact of passive hyperthermia on the executive control function

作　　者：李勃[1] 钱绍文[1] 刘锴[1] 姜庆军[1] 孙钢[1] 

机构地区：[1]济南军区总医院医学影像科,山东 济南250031

出　　处：《实用放射学杂志》2015年第7期1061-1065,共5页Journal of Practical Radiology

基　　金：中国博士后科学基金项目（2014M552596）.

摘　　要：目的：采用 Granger 因果分析（GCA）方法探讨高温状态下被试者进行注意网络（ANT）任务中执行网络激活区域间的因果关系。方法将30例男性健康被试者随机分为试验组与对照组,每组15例。分别在高温（50℃）与常温（20℃）下进行 ANT 并采集功能磁共振（fMRI）数据。利用 SPM8对 fMRI 数据进行分析,对脑激活结果进行 Granger 因果分析,并分别计算常温及高温组激活脑区间 Granger 因果关系（GC）值与反应时间之间的相关性。结果2组比较 Granger 因果分析显示：前扣带回对背外侧前额叶皮质的影响增强、背外侧前额叶皮质与右顶上小叶双向因果关系增强、右顶上小叶与右顶下小叶因果关系减弱、右顶下小叶对背外侧前额叶皮质因果关系增强。常温组的反应时与右顶上小叶对背外侧前额叶皮质的影响呈负相关（r=-0.558,P=0.031）,高温组无明显相关（r=0.355,P =0.257）。结论高温负荷影响了执行网络脑区间有效连接,这种有效连接的变化影响了人脑的执行控制能力。Objective To explore the causal influences between activated regions in executive control network when participants were performing attention network test （ANT）under passive hyperthermia using Granger causality analysis.Methods Thirty male healthy participants which were randomly divided into control group （n=1 5）and experimental group （n=1 5）performed ANT task during two thermal conditions：hyperthermic condition （50℃）and normothermic condition （20℃）during functional magnetic reso-nance imaging.The data processing was performed using statistical parametric mapping 8 （SPM8）.Granger causality analysis was performed on the resulted activated regions,as well as the correlations of the GC values with the reaction time in both groups.Results Between-group comparisons on Granger causality analysis revealed significantly enhanced influences of anterior cingulate gyrus and right inferior parietal lobule on dorsolateral prefrontal cortex,and bidirectional influences between dorsolateral prefrontal cortex and right superior parietal lobule,but decreased influence between right superior parietal lobule and right inferior parietal lobule.The correlation analysis showed significant correlation between GC value of right superior parietal lobule to dorsolateral prefrontal cortex and the reaction time in control group （r=-0.558,P =0.031）,but yet there was no significant correlation in experimental group （r=0.355,P =0.257）.Conclusion Heat stress affected the causal influences within the executive control network,which subse-quently disrupted the executive control performance during passive hyperthermia.

关 键 词：注意网络 GRANGER因果分析 高温 

分 类 号：R322.81[医药卫生—人体解剖和组织胚胎学] R445.2[医药卫生—基础医学]