鹿茸多肽的抗疲劳作用机制研究  

Study on Antifatigue Mechanism of Pilose Antler Polypeptides

作　　者：胡太超[1,2] 刘玉敏 陶荣珊[1] 苏凤艳[1] 张晶[1,3] 李庆杰[4] 王全凯[1,2] 

机构地区：[1]吉林农业大学中药材学院,长春130118 [2]吉林省中韩动物科学研究院,长春130600 [3]长春科技学院,长春130600 [4]长春中医药大学附属医院,长春130021

出　　处：《吉林农业大学学报》2015年第4期469-476,共8页Journal of Jilin Agricultural University

基　　金：国家国际科技合作专项(2011DFA32900);吉林省科技发展计划项目(20120246;20100718)

摘　　要：通过游泳试验建立小鼠疲劳模型,测定了鹿茸多肽对小鼠游泳时间、肝糖原、肌糖原、尿素氮(BUN)、乳酸(LA)、乳酸脱氢酶(LDH)、丙二醛(MDA)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)等指标的影响。结果表明:鹿茸多肽可增加小鼠肝糖原和肌糖原的含量,显著降低代谢产物LA、MDA、BUN的水平,提高LDH、SOD、GSH-Px活性,加速自由基的清除,增强小鼠的抗氧化能力,提高小鼠的运动能力,起到抗疲劳作用。Fatigue model was established by swimming test. Effects of PAP on swimming time,liver glycogen,muscle glycogen,serum urea nitrogen,lactic acid,LDH,MDA,SOD,GSH-Px were determined. The results show that pilose antler polypeptides increased content of liver glycogen and muscle glycogen,significantly reduced metabolic product of LA,BUN and MDA levels,increased LDH,SOD and GSH-Px activities,accelerated clearance of free radical,enhanced mice antioxidant capacity and improved exercise ability of mice. Pilose antler polypeptides have the effect of antifatigue.

关 键 词：鹿茸多肽 抗疲劳 小鼠 

分 类 号：R285.5[医药卫生—中药学]