毒代动力学方法指导治疗急性汞中毒——自服“纳氏试剂”致汞中毒合并胃食管灼伤1例  

The treatment of acute mercurialism which guicled by toxicokinetics——A case report of nessle reagent induced acute mercurialism combined with gastric esophageal burns

作　　者：王义辉[1] 盛慧球[1] 童建菁[1] 叶静[1] 陆一鸣[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院急诊部,上海200025

出　　处：《临床急诊杂志》2015年第7期510-512,共3页Journal of Clinical Emergency

摘　　要：目的:探讨毒代动力学方法在汞中毒治疗中的运用。方法:报道自服"纳氏试剂"致汞中毒合并胃食管灼伤1例,通过监测汞浓度变化,运用毒代动力学指导治疗。结果:通过二巯丙磺酸钠(DMPS)解毒治疗后患者汞代谢半衰期明显缩短,并根据半衰期评估治疗效果及调整DMPS用量。结论:建议在实际临床中运用毒代动力学指导汞中毒治疗。Objective：To investigate the application of toxicokinetics as a guideline in treatment of mercurialism.Method：A case of nessle reagent induced acute mercurialism combined with gastric esophageal burns was reported.The mercury＇s concentration was monitored,and toxicokinetics was used to guide the treatment.Result：The half-life of circulating mercurial metabolism rate was obviously reduced after receiving the DMPS treatment.The treatment effectiveness was evaluated and the dose of DMPS was adjusted based on the half-life of mercurial metabolism.Conclusion：Toxicokinetics based methods are recommended as a novel treatment for mercurialism in clinical aspects.

关 键 词：毒物代谢动力学 急性汞中毒 胃食管灼伤 

分 类 号：R595.2[医药卫生—内科学]