血清淀粉样蛋白A对急诊脓毒症患者诊断的意义  

Clinical significance of serum amyloid A for the diagnosis of sepsis in emergengcy patients

作　　者：谢春明[1] 刘宏锋[1] 

机构地区：[1]佛山市第一人民医院急诊科,广东佛山528000

出　　处：《岭南现代临床外科》2015年第4期504-506,共3页Lingnan Modern Clinics in Surgery

基　　金：佛山市卫计局医学科研课题(2013212)

摘　　要：目的检测血清淀粉样蛋白A(SAA)并与降钙素原(PCT)比较,探讨其对急诊脓毒症患者早期诊断的价值,以指导临床诊疗。方法回顾性分析2013年7月至2014年12月我院急诊收治的68例符合纳入标准患者的临床资料,根据最终诊断分为脓毒症组和非感染性SIRS组,比较两组间血清SAA和PCT含量,绘制诊断脓毒症的受试者工作曲线(ROC曲线)。结果脓毒症组患者血清SAA、PCT浓度显著高于非感染性SIRS组,差异有统计学意义(P<0.01);SAA、PCT诊断脓毒症的ROC曲线下面积分别为0.773±0.057、0.938±0.026,两者有统计学差异(P<0.05);SAA、PCT各自截断点的诊断准确率为70.6%和85.3%。结论 SAA、PCT两项指标对早期诊断脓毒症均有一定的价值,PCT的诊断效能强于SAA。Objective To investigate the diagnostic value of serum amyloid A （SAA） by comparison between SAA and procalcitonin （PCT）. Methods Sixty-eight patients with sepsis were included in the study and were divided into two groups according to final diagnosis, sepsis group and non-infectious origin of systemic inflammatory response syndrome group （SIRS group）. Serum SAA and PCT levels were determined and evaluated diagnostic significance by receiver operating characteristic curves （ROC）. Results The levels of serum SAA and PCT in septic patients were significantly increased than that in non-infectious SIRS patients （P〈0.001）. Areas under ROC of SAA and PCT in the diagnosis of sepsis were 0.773±0.057 in SAA, 0.938±0.026 in PCT （SAA versus PCT,P〈0.05）. The accurate diagnostic rate of SAA was 70.6% and PCT 85.3%, while there were significant difference between them. Conclusion SAA, PCT have a same value for diagnosis of sepsis, but the later has advantage over the former.

关 键 词：脓毒症 血清淀粉样蛋白A 降钙素原 诊断 

分 类 号：R631[医药卫生—外科学]