白细胞群落参数用于骨髓移植后造血重建的预测评估  

Clinical evaluation of cell population data parameters in predicting engraftment after hematopoietic stem cell transplantation

作　　者：邢莹[1] 屈晨雪[1] 王美玲[1] 王玎玲[1] 宋一楠[1] 汪润[1] 朱鹰[1] 李金美[1] 

机构地区：[1]北京大学第一医院检验科,100034

出　　处：《中华医学杂志》2015年第28期2282-2284,共3页National Medical Journal of China

摘　　要：目的 评价DxH800血细胞分析仪中白细胞群落（CPD）参数用干预测骨髓移植后造血重建的可行性.方法 选取2013年7月至2014年9月于北京大学第一医院进行骨髓移植的患者109例,调取从移植当天到粒系植活（中性粒细胞绝对计数＞ 500个/μl）期间每天的血细胞计数（CBC）结果,分析其CPD参数,找到与植活相关的参数并确定临界值.结果 具有预测意义的参数是中性粒细胞平均体积（MNV）和单核细胞平均体积（MMV）,其临界值分别为≥180 fl和≥190 fl,分别比中性粒细胞绝对计数提前预测（2.2±1.3）d和（2.3±1.7）d.结论 通过分析DxH800血细胞分析仪的CPD参数,大约可以比中性粒细胞绝对计数提前2d预测粒系植活.Objective To explore the cell population data （CPD） parameters of DxH800 hematology analyzer in predicting engraftment after hematopoietic stem cell transplantation.Methods Data from 109 patients who underwent hematopoietic stem cell transplantation at Peking University First Hospital between July 2013 and September 2014 were selected,all CBC data including CPD parameters from the beginning to engraftment （absolute neutrophil count ＞ 500/μl） were gathered and analyzed to find the early markers of myeloid engraftment and establish the cut-off value.Results The makers which could predict myeloid engraftment were mean neutrophil volume （MNV） and mean monocyte volume （MMV）,the cut-off value was ≥180 fl and≥190 fl,respectively,and engraftment was predicted earlier （2.2 ± 1.3） days and （2.3 ± 1.7） days than absolute neutrophil count.Conclusion By analyzing the CPD data of DxH800 hematology analyzer,engraftment can be predicted approximately 2 days earlier than absolute neutrophil count.

关 键 词：骨髓移植 中性粒细胞 单核细胞 

分 类 号：R457.7[医药卫生—治疗学]