中药复方通腑颗粒对老年脓毒症患者肠屏障功能的影响  

Effect of Compound Tongfu Granule on Intestinal Permeability in Elderly Sepsis Patients

作　　者：姜春燕[1] 徐艳霞[2] 郝瑞瑞[1] 王丹[1] 王俊雄[1] 罗佳[1] 张伟[1] 陈海平[1] 李敏[1] 李昂[1] 

机构地区：[1]首都医科大学附属北京友谊医院医疗保健中心,北京100050 [2]首都医科大学化学生物学与药学院,北京100069

出　　处：《中国中西医结合杂志》2015年第7期787-791,共5页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：北京市中医管理局青年科学研究资助项目(No.QN2011-08);首都医科大学基础临床合作研究基金资助项目(No.12JL38)

摘　　要：目的探讨中药复方通腑颗粒对老年脓毒症患者肠通透性的影响。方法采用随机双盲试验方案,将80例老年脓毒症患者分为试验组和对照组,每组40例,在常规脓毒症治疗方案的基础上,试验组服用通腑颗粒,对照组服用安慰剂,均14.3 g/袋,每日2次,每次1袋,疗程14天。比较治疗前后两组患者腹部症状体征、血清炎症因子(高敏C反应蛋白、降钙素原)、血浆内毒素水平及肠通透性(尿乳果糖/甘露醇排出率)的变化。结果治疗14天后,与对照组比较,试验组腹胀症状改善,排便次数增多,血浆内毒素及肠通透性水平显著降低(P<0.05)。结论中药复方通腑颗粒可改善老年脓毒症患者的肠屏障功能。Objective To explore the effect of Compound Tongfu Granule（ CTG） on intestinal permeability in elderly sepsis patients. Methods Eighty elderly sepsis patients were randomly assigned to the experimental group and the control group by randomized double blinded method,40 in each group. On the basis of conventional anti-septic treatment program,patients in the experimental group took CTG,while those in the control group took placebos. The dosage for CTG or placebos was 14. 3g each package,one package each time,twice daily for 14 successive days. Patients＇ abdominal symptoms and signs,levels of serum inflammatory factors（ high-sensitivity C-reactive protein and procalcitonin）,levels of plasma endotoxin,and the intestinal permeability（ IP,represented by urinary lactulose / mannitol excretion rate） were compared between the two groups before and after treatment. Results After 14-day treatment,patients in the experimental group had improved abdominal symptoms,increased frequency of defecation,significantly decreased levels of plasma endotoxin and IP,when compared with the control group（P〈0. 05）. Conclusion CTG could improve the intestinal barrier function in elderly sepsis patients.

关 键 词：通腑颗粒 老年 脓毒症 肠通透性 随机对照双盲试验 

分 类 号：R459.7[医药卫生—急诊医学]