养血散寒颗粒治疗糖尿病周围神经病变  

Yangxue Sanhan Granule in Treating Diabetic Peripheral Neuropathy

作　　者：邹本良[1] 张广德[1] 王燕秋[1] 邵鑫[1] 魏子孝[1] 

机构地区：[1]中国中医科学院西苑医院,北京100091

出　　处：《中国实验方剂学杂志》2015年第15期156-159,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：中国中医科学院优势病种项目(ZYK2005Y1102012-1)

摘　　要：目的:观察养血散寒颗粒治疗糖尿病周围神经病变(气血不足、寒湿痹阻型)临床疗效。方法:60例糖尿病周围神经病变患者随机平均分为治疗组和对照组,两组均进行基础降糖治疗。治疗组给予养血散寒颗粒治疗,对照组给予甲钴胺片治疗。两组均进行中医症状计分,测神经传导速度。试验共计12周。试验结束后进行两组症状计分、神经传导速度疗效比较。结果:治疗组总有效率为72.41%,对照组有效率为14.29%,两组比较差异有统计学意义(P<0.05);两组治疗前后自身比较中医证候积分均明显降低(P<0.01),治疗后两组间中医证候积分比较有统计学差异(P<0.01);治疗组和对照组神经传导速度在组内、组间比较均无显著性差异。结论:养血散寒颗粒治疗气血不足、寒湿痹阻型糖尿病周围神经病变可以有效改善临床症状,尤其对疼痛、乏力症状改善明显。临床综合疗效优于甲钴胺片治疗。两组对改善神经传导速度均不明显。Objective： To observe the clinical therapeutic effect of Yangxue Sanhan granule in treating the diabetic peripheral neuropathy（ Qi and blood deficiency,cold-dampness syndrome）. Method： Totally sixty patients with diabetic peripheral neuropathy were randomly divided into the treatment group and the control group and treated for the basic hypoglycemia. The treatment group was administered with Yangxue Sanhann granules,while the control group was given mecobalamine tablets. The study lasted for 12 weeks. The traditional Chinese medicine（ TCM） symptom score and nerve conduction velocity of both groups were detected during and after the study. Result： The total effective rate of the treatment group was 72. 41%,and that of the control group was14. 29%,with statistical differences（ P 〈 0. 05）. Both groups showed lower TCM symptom scores compared with their own scores before and after the treatment（ P 〈 0. 01） and statistical differences in TCM symptom scores after the treatment（ P 〈 0. 01）,without intra-group and inter-grioup significant difference in the nerve conduction velocity. Conclusion： Yangxue Sanhan granules can treat the diabetic peripheral neuropathy（ Qi and blood deficiency,cold-dampness syndrome）,effectively improve the clinical symptoms,particularly such symptoms as pain and fatigue,with a better comprehensive clinical efficacy than mecobalamine tablets. However,both groups showed no notable improvement in the nerve conduction velocity.

关 键 词：养血散寒颗粒 气血不足 寒湿痹阻型 糖尿病周围神经病变 

分 类 号：R287.6[医药卫生—中药学]