高强纯音声损伤鸡耳蜗后毛细胞再生研究  

Hair Cell Regeneration and Recovery Following Intense Sound Exposure Induced Damage in the Chick Cochlea

作　　者：李胜利[1] 朱宏亮[1] 张全忠[1] 白秦生[1] 

机构地区：[1]西安医科大学第二附属医院耳鼻咽喉科

出　　处：《听力学及言语疾病杂志》1994年第2期78-80,共3页Journal of Audiology and Speech Pathology

摘　　要：本文报告给２天日龄雏鸡每日１．５ｋＨｚ１２０ｄＢＳＰＬ高强纯音暴露８小时，共刺激６天；随后分０．１、２和３周处死动物，其耳蜗基底乳头（Ｂｐ）行扫描电镜（ＳＥＭ）和光镜（ＬＭ）观察，结果发现１．５ｋＨｚ强纯音仅造成鸡Ｂｐ基部至中部内侧较窄范围毛细胞损害，毛细胞消失率占３０％左右；当恢复１周后，受损处毛细胞迅速再生，至恢复２周后Ｂｐ基本正常。证明高强度纯音损害鸡内耳后受损区毛细胞有再生能力，再生毛细胞发育成熟而使Ｂｐ恢复正常形态。Two-day-old chicks were exposed to intense pure tone of 1.5 kPa 120 dBSPL for 8 h per day lasted 5 days and their cochleae were processed for both scanning electron microscopy and light microscopy at 1,2,3 and 4 weeks following the last injection,so as to examine hair cell regenration and recovery in the cochlea.The result was found that hair cell loss was in the basal to middle basilar papila following acoustic trauma.By two weeks post-recovery,however,most of the damaged region had been replaced with regeneration hair cells.By four weeks post recovery,the regeneration hair cell developed normal sensory hair cells.This experiment demonstrated that the hair cells were able to regeneration and recover in the cochlea basilar papilla following sound induced trauma.

关 键 词：高强纯音声损伤 鸡 耳蜗 毛细胞再生 内耳毛细胞损害 

分 类 号：R764.35[医药卫生—耳鼻咽喉科]