冠状动脉微血管病变与心肌梗死后不良心室重构  

Relationship between coronary microvascular dysfunction and adverse ventricular remodeling after myocardial infarction

作　　者：王朝晖[1] 李文珠[1] 

机构地区：[1]华中科技大学附属协和医院老年病科,武汉430022

出　　处：《临床心血管病杂志》2015年第7期693-695,共3页Journal of Clinical Cardiology

摘　　要：不良心室重构(AVR)是心肌梗死(MI)后心室破裂和心力衰竭发生的病理基础,其程度依赖于心肌缺血程度、心肌梗死面积和修复质量。当今MI治疗从早期仅解决大血管斑块阻塞转变为同时关注冠脉微血管病变(CMVD),挽救存活心肌细胞的新策略。大量证据表明,影响CMVD的病理和分子机制众多且复杂,在时间和空间上相互作用而促进、维持和加剧AVR的发生和发展。故探索CMVD与AVR的关系及其病理生理机制,对制定冠心病治疗策略有重要意义。Summary Adverse ventricular remodeling（AVR）after myocardial infarction（MI）is the pathological basis of ventricular rupture and heart failure.Moreover,the degree of ventricular remodeling depends on the extent of myocardial ischemia/infarct size and quality of healing.Earlier myocardial infarction treatment strategy merely focus on ＂the plaque-related obstruction＂,whereas coronary microvascular dysfunction and saving viable cardiomyocytes are emphasized in the new guideline recently.It has been evidenced in various experimental studies and clinical trials that the pathology and molecular mechanisms of CMVD are numerous and complex.The spatially and temporally overlap of CMVD promote,maintain and exacerbate AVR.Thus,it＇s necessary to explore the underlying relationship between CMVD and AVR after MI,which is significant to future treatment strategies.

关 键 词：微血管病变 心肌梗死 心室重构 

分 类 号：R541.1[医药卫生—心血管疾病]