吸烟对亚临床甲状腺功能减退患者颈动脉粥样硬化的影响  

The impact of smoking on carotid atherosclerosis degree in patients with subclinical hypothyroidism

作　　者：杨萍[1] 殷国田[2] 

机构地区：[1]新乡医学院第三附属医院内分泌科,河南新乡453003 [2]新乡医学院第三附属医院心内科

出　　处：《临床心血管病杂志》2015年第7期745-747,共3页Journal of Clinical Cardiology

基　　金：河南省科技厅基金项目(No:132102310166)

摘　　要：目的:探讨吸烟对亚临床甲减患者颈动脉粥样硬化的影响。方法:选取63例亚临床甲减男性患者,分为吸烟组33例和非吸烟组30例,并选取同期来本院体检的46例健康男性为对照组。检测所有受试者的血脂水平和颈动脉内膜中层厚度(IMT),并对各组结果进行比较分析。结果:非吸烟组、吸烟组的血浆TG、TC、LDLC、颈动脉IMT均高于对照组(均P<0.01),吸烟组的血浆TG、TC、LDL-C、颈动脉IMT高于非吸烟组(均P<0.05);非吸烟组、吸烟组的血浆HDL-C均低于对照组(均P<0.01),吸烟组的血浆HDL-C低于非吸烟组(P<0.05)。结论:吸烟可加重亚临床甲减患者的血脂异常和颈动脉粥样硬化程度,应尽早进行临床干预。Objective：To analyze the influence of smoking on carotid atherosclerosis degree in patients with subclinical hypothyroidism.Method：A total of 63 male patients with subclinical hypothyroidism and 30 male cases of healthy check-up（control group）were enrolled in the study.All the patients were divided into two groups：smoking group（n=33）and non-smoking group（n=30）.The blood lipid levels,carotid intima-media thickness（IMT）in all cases were detected and analyzed comparatively.Result：Plasma TG,TC,LDL-C levels and carotid IMT in smoking group combined with non-smoking group were significantly higher than those in control group（all P〈0.01）.Smoking group had greater TG,TC,LDL-C levels and carotid IMT than those in non-smoking group（all P〈0.05）.Plasma HDL-C levels in smoking group and non-smoking group were significantly lower than those in control group（both P〈0.01）.Smoking group had lower HDL-C levels than that in non-smoking group（P〈0.05）.Conclusion：Smoking can aggravate dyslipidemia and carotid atherosclerosis in subclinical hypothyroidism patients,so early clinical invervention in these patients is very essential.

关 键 词：吸烟 亚临床甲状腺功能减退 颈动脉粥样硬化 

分 类 号：R581.2[医药卫生—内分泌]