呼出气一氧化氮检测在支气管哮喘临床诊断中的应用  

Application of FeNO Detection in the Clinical Diagnosis of Bronchial Asthma

作　　者：陈钊成 陈必达[1] 张卫芳 张建芳[1] 吴峰[1] 

机构地区：[1]惠州市第三人民医院呼吸科,广东惠州516002 [2]惠州市卫生职业技术学院,广东惠州516025

出　　处：《黑龙江医学》2015年第6期650-651,共2页Heilongjiang Medical Journal

基　　金：2014年惠州市科技计划项目(2014Y144)

摘　　要：目的研究呼出气一氧化氮（Fe NO）检测在支气管哮喘临床诊断中的应用。方法选择2014-05~2014-12间在我院确诊的65例支气管哮喘患者作为观察组,同时选择30例的正常人作为健康对照组,测定两组研究对象的Fe NO浓度以及诱导痰嗜酸性粒细胞计数,同时评定Fe NO情况与哮喘控制测试（ACT）的评分之间的关系。结果健康对照组人群的Fe NO浓度明显低于观察组Fe NO浓度,差异具有统计学的意义（P〈0.05）;同时,健康对照组诱导痰嗜酸性粒细胞计数也明显少于观察组的诱导痰嗜酸性粒细胞计数,差异具有统计学的意义（P〈0.05）,且通过测定Fe NO及诱导痰嗜酸性粒细胞计数进行诊断时患者的阳性率依次是95.38%、81.54%。同时,哮喘患者的Fe NO情况和ACT的评分之间呈现负相关,（r=-0.33,P〈0.05）。结论 Fe NO检测能够有效地对支气管哮喘患者进行诊断。Objective To research the application of exhaled nitric oxide（ Fe NO） detection in the clinical diagnosis of bronchial asthma. Methods In the research,choosing 65 cases who were diagnosed as bronchial asthma in the hospital from May,2014 to December,2014 as the observation group,while 30 cases of normal health as control group. Measuring concentration of Fe NO and the inducing sputum eosinophil count. At the same time,assessing the relationship between Fe NO and ACT scores. Results After the research,the concentration of Fe NO among healthy persons was significantly lower than the observation group,and the data was statistically significant（ P〈0. 05）; while the induced sputum eosinophil count of control group was significantly less than the induced sputum eosinophil count of observation group,and the data was statistically significant（ P〈0. 05）. And the positive rate by measuring Fe NO and induced sputum eosinophil counts were 95. 38% and 81. 54%. At the same time,the relationship between asthmatics Fe NO and ACT score showed negative correlation（ r =- 0. 33,P〈〈 0. 05）. Conclusion The exhaled nitric oxide（ FeNO） detection can effectively diagnose patients with bronchial asthma.

关 键 词：呼出气一氧化氮 支气管哮喘 哮喘控制测试 

分 类 号：R562.25[医药卫生—呼吸系统]